Abstract: Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or cellular damages. The process leads to an auto-activation of caspase-1 and consequent maturation of caspase-1 target molecules such as interleukin (IL)-1β and IL-18. Recently, the role of caspase-1 and inflammasome in inflammatory-induced noncommunicable diseases (NCDs) like obesity, diabetes mellitus (DM), cardiovascular diseases (CVDs), cancers and chronic respiratory diseases have widely studied. However, their reports are distinct and even they have reported contrasting role of caspase-1 in the development and progression of NCDs. A few studies have reported that caspase-1/inflammasome assembley has a protective role in the initiation and progression of these diseases through the activation of the noncanonical caspase-1 target substrates like gasdermin-D and regulation of immune cells. Conversely, others have revealed that caspase-1 has a direct/indirect effect in the development and progression of several NCDs. Therefore, in this review, we systematically summarized the role of caspase-1 in the development and progression of NCDs, especially in obesity, DM, CVDs and cancers.

Keywords: caspase-1, inflammasome, IL-1β, IL-18, noncommunicable diseases


中文翻译：

---

Caspase-1在与炎症有关的慢性非传染性疾病发病机理中的作用

摘要：Caspase-1是第一个经过广泛研究的炎性半胱天冬酶，可通过炎症小体组装激活。炎症小体是多蛋白复合物的胞质形成，旨在开始针对感染或细胞损伤的炎症反应。该过程导致caspase-1的自动激活，并导致caspase-1靶分子（如白介素（IL）-1β和IL-18）成熟。最近，对caspase-1和炎性体在炎症引起的非传染性疾病（NCD）（例如肥胖症，糖尿病（DM），心血管疾病（CVD），癌症和慢性呼吸道疾病）中的作用进行了广泛的研究。然而，他们的报道截然不同，甚至他们都报道了caspase-1在非传染性疾病发展和进程中的对比作用。一些研究报告称，通过激活非经典的caspase-1靶标底物（如Gasdermin-D）和调节免疫细胞，caspase-1 /炎症小体装配体在这些疾病的发生和发展中具有保护作用。相反，其他人则发现caspase-1在几种NCD的发生和发展中具有直接/间接作用。因此，在这篇综述中，我们系统地总结了caspase-1在NCD的发生和发展中的作用，尤其是在肥胖，DM，CVD和癌症中。其他人发现，胱天蛋白酶-1在几种非传染性疾病的发生和发展中具有直接/间接作用。因此，在这篇综述中，我们系统地总结了caspase-1在NCD的发生和发展中的作用，尤其是在肥胖，DM，CVD和癌症中。其他人发现，胱天蛋白酶-1在几种非传染性疾病的发生和发展中具有直接/间接作用。因此，在这篇综述中，我们系统地总结了caspase-1在NCD的发生和发展中的作用，尤其是在肥胖，DM，CVD和癌症中。

关键词： caspase-1，炎性体，IL-1β，IL-18，非传染性疾病