Perimidines are peri-naphtho-fused derivatives of pyrimidine. They are of particular interest as they are a rare example of an azine in which the lone pair of electrons of pyrrole-like nitrogen participates in the π-system of the molecule. Perimidine is an interesting class of heterocyclic compounds. Various synthetic analogs of perimidines have been prepared and evaluated for many pharmacological activities in different models with desired findings. They exhibit biological activities as antitumor, antiulcer, antimicrobial, and antifungal agents. This review is an attempt to organize the synthesis and chemical reactions of perimidine analogs reported to date systematically since 1955. It should be noted that this review is the first one that includes the preparation and reactions of the perimidine ring.

Perimidines是嘧啶的环萘融合衍生物。它们特别令人感兴趣，因为它们是嗪的罕见实例，其中吡咯状氮的孤电子对参与分子的π系统。Perimidine是一类有趣的杂环化合物。已经制备了各种嘧啶的合成类似物，并在具有所需发现的不同模型中评估了其许多药理活性。它们表现出生物活性，例如抗肿瘤，抗溃疡，抗微生物和抗真菌剂。这项综述是自1955年以来系统地组织迄今报道的perimidine类似物的合成和化学反应的尝试。应该指出的是，该综述是首次包括perimidine环的制备和反应的综述。