This study aimed to determine discrepancies in the urinary glycosaminoglycan profiles of autism spectrum disorder (ASD) patients (n=9) when compared with those from healthy volunteers (HVs, n=3). The guardians and/or educators for each participant also returned a validated Autism Behavior Checklist (ABC). The urinary chondroitin sulfate (CS) concentration was 46.1% lower in the ASD group than in the HV group. The ABC score and the urinary CS concentration were negatively correlated (Spearman's coefficient of -0.2635), indicating that as the severity of the clinical aspect of this disorder increased, the urinary CS concentration decreased. These results suggest that low CS concentrations in the urine may be associated with ASD, and could be measured using a fast and low-cost method for diagnostics.

中文翻译：

---

自闭症谱系障碍：可能与软骨素硫酸盐有关

这项研究旨在确定自闭症谱系障碍（ASD）患者（n = 9）与健康志愿者（HVs，n = 3）的尿糖胺聚糖谱差异。每个参与者的监护人和/或教育者还返回了经过验证的自闭症行为清单（ABC）。ASD组的尿硫酸软骨素（CS）浓度比HV组低46.1％。ABC评分与尿液CS浓度呈负相关（Spearman系数为-0.2635），表明随着该疾病临床方面的严重性增加，尿液CS浓度降低。这些结果表明，尿液中CS浓度低可能与ASD有关，可以使用快速，低成本的方法进行诊断。