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NanoGalaxy: Nanopore long-read sequencing data analysis in Galaxy
GigaScience ( IF 11.8 ) Pub Date : 2020-10-17 , DOI: 10.1093/gigascience/giaa105
Willem de Koning 1, 2 , Milad Miladi 3 , Saskia Hiltemann 1 , Astrid Heikema 4 , John P Hays 4 , Stephan Flemming 3 , Marius van den Beek 5 , Dana A Mustafa 2 , Rolf Backofen 3 , Björn Grüning 3 , Andrew P Stubbs 1
Affiliation  

Long-read sequencing can be applied to generate very long contigs and even completely assembled genomes at relatively low cost and with minimal sample preparation. As a result, long-read sequencing platforms are becoming more popular. In this respect, the Oxford Nanopore Technologies–based long-read sequencing “nanopore" platform is becoming a widely used tool with a broad range of applications and end-users. However, the need to explore and manipulate the complex data generated by long-read sequencing platforms necessitates accompanying specialized bioinformatics platforms and tools to process the long-read data correctly. Importantly, such tools should additionally help democratize bioinformatics analysis by enabling easy access and ease-of-use solutions for researchers.

中文翻译:


NanoGalaxy:Galaxy中的Nanopore长读长测序数据分析



长读长测序可用于以相对较低的成本和最少的样品制备生成非常长的重叠群,甚至完全组装的基因组。因此,长读长测序平台变得越来越流行。在这方面,基于牛津纳米孔技术公司的长读长测序“纳米孔”平台正在成为一种广泛使用的工具,具有广泛的应用和最终用户。然而,需要探索和操作长读长测序生成的复杂数据。读取测序平台需要附带专门的生物信息学平台和工具来正确处理长读取数据,重要的是,此类工具还应通过为研究人员提供轻松访问和易用的解决方案来帮助实现生物信息学分析的民主化。
更新日期:2020-10-20
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