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Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment
Frontiers in Chemistry ( IF 3.8 ) Pub Date : 2020-09-17 , DOI: 10.3389/fchem.2020.564809
Jingshun Zhang , Ying Xu , Dandan Li , Lulu Fu , Xueying Zhang , Yigang Bao , Lianwen Zheng

LAT1 is a member of the system L transporter family. The main role of the LAT1 is to transport specific amino acids through cell membranes to provide nutrients to cells and participate in several metabolic pathways. It also contributes to the transport of hormones and some drugs, which are essential for the development and treatment of some diseases. In recent years, many studies have shown that LAT1 is related to cancer, obesity, diabetes, and other diseases. However, the specific mechanism underlying the influence of LAT1 on such conditions remains unclear. Through the increasing number of studies on LAT1, we have obtained a preliminary understanding on the function of LAT1 in diseases. These studies also provide a theoretical basis for finding treatments for LAT1-related diseases, such as cancer. This review summarizes the function and mechanism of LAT1 in different diseases and the treatment of LAT1-related diseases. It also provides support for the development of novel and reliable disease treatments.



中文翻译:

LAT1与疾病的相关性综述:机理与治疗

LAT1是系统L转运蛋白家族的成员。LAT1的主要作用是通过细胞膜转运特定氨基酸,为细胞提供营养,并参与多种代谢途径。它还有助于荷尔蒙和某些药物的运输,这对于某些疾病的发展和治疗至关重要。近年来,许多研究表明,LAT1与癌症,肥胖症,糖尿病和其他疾病有关。但是,LAT1影响这种条件的具体机制仍不清楚。通过对LAT1的越来越多的研究,我们对LAT1在疾病中的功能有了初步的了解。这些研究也为寻找与LAT1相关的疾病(例如癌症)的治疗方法提供了理论基础。这篇综述总结了LAT1在不同疾病中的功能和机制以及与LAT1相关的疾病的治疗。它还为开发新型可靠的疾病治疗方法提供了支持。

更新日期:2020-10-20
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