We conducted a cross-sectional study among 194 pregnant women from two low-income settings in Cambodia. The inclusion period lasted from October 2015 through December 2017. Maternal serum samples were analyzed for persistent organic pollutants (POPs). The aim was to study potential effects on birth outcomes. We found low levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCP), except for heptachlors, β-hexachlorocyclohexane (HCH), heptachlor epoxide, and p,p’-DDE. There were few differences between the two study locations. However, the women from the poorest areas had significantly higher concentrations of p,p’-DDE (p < 0.001) and hexachlorobenzene (HCB) (p = 0.002). The maternal factors associated with exposure were parity, age, residential area, and educational level. Despite low maternal levels of polychlorinated biphenyls, we found significant negative associations between the PCB congeners 99 (95% CI: −2.51 to −0.07), 138 (95% CI: −1.28 to −0.32), and 153 (95% CI: −1.06 to −0.05) and gestational age. Further, there were significant negative associations between gestational age, birth length, and maternal levels of o,p’-DDE. Moreover, o,p’-DDD had positive associations with birth weight, and both p,p’-DDD and o,p’-DDE were positively associated with the baby’s ponderal index. The poorest population had higher exposure and less favorable outcomes.

中文翻译：

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孕妇中某些有机氯的血清浓度以及与妊娠结局的关系。柬埔寨两个农村地区的跨部门研究

我们对来自柬埔寨两个低收入地区的194名孕妇进行了横断面研究。纳入时间为2015年10月至2017年12月。分析了孕妇血清样本中的持久性有机污染物（POPs）。目的是研究对出生结局的潜在影响。我们发现，除了七氯，β-六氯环己烷（HCH），七氯环氧化物和p，p'-DDE外，多氯联苯（PCBs）和有机氯农药（OCP）的含量较低。两个研究地点之间几乎没有差异。然而，来自最贫困地区的妇女的p，p'-DDE（p <0.001）和六氯苯（HCB）（p= 0.002）。与接触有关的孕产妇因素是平价，年龄，居住区和教育程度。尽管母体中的多氯联苯含量较低，但我们发现PCB同类物99（95％CI：-2.51至-0.07），138（95％CI：-1.28至-0.32）和153（95％CI： -1.06至-0.05）和胎龄。此外，胎龄，出生时间和母亲体内o，p'-DDE水平之间存在显着的负相关。此外，o，p'-DDD与出生体重呈正相关，而p，p'-DDD和o，p'-DDE均与婴儿的体重指数呈正相关。最贫穷的人口接触率较高，而结局则较差。