Objectives: 

Prevalence of cardiovascular disease increases with age. Little is known about the prevalence and risk factors for echocardiographic abnormalities among older people living with HIV (PLHIV) from Asia.

Design: 

A cross-sectional study was conducted among PLHIV aged >50 years (N = 298) on antiretroviral treatment (ART) and HIV-negative controls (N = 100) frequency matched by sex and age in Thailand.

Methods: 

All participants underwent standard 2-dimensional transthoracic echocardiography performed by trained cardiologists who were blinded to the participant's care and HIV status. Logistic regression was used to examine the association between cardiac abnormalities and risk factors.

Results: 

The median age was 54.7 years (60.8% men) with 37.2% having hypertension and 16.6% having diabetes mellitus. PLHIV was on ART for a median of 16.2 years with current CD4 cell counts of 616 cells per cubic millimeter. Echocardiogram abnormalities did not differ among PLHIV (55%) and the controls (60%). The major abnormalities in PLHIV were following: left ventricular (LV) hypertrophy: 37% men and 42.2% women, LV systolic dysfunction (0.7%), diastolic dysfunction (24.2%), and pulmonary hypertension (3.9%). From the multivariate analyses in PLHIV, being aged >60 years was independently associated with diastolic dysfunction, whereas female sex and left atrial volume index of >34 mL/m² were associated with pulmonary hypertension (P < 0.05). None of the ART was significantly associated with any major echocardiographic abnormalities.

Conclusions: 

In this long-term, well-suppressed, older, Asian PLHIV cohort, the prevalence of asymptomatic LV systolic dysfunction and pulmonary hypertension were relatively low, whereas the diastolic dysfunction and LV hypertrophy were common. Echocardiographic findings did not differ between PLHIV and HIV-uninfected controls.

中文翻译：

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病毒抑制的艾滋病毒感染的亚裔亚洲人与艾滋病毒阴性个体之间的超声心动图发现

目标： 

心血管疾病的患病率随年龄增长而增加。对于来自亚洲的艾滋病毒感染者（PLHIV）的超声心动图异常的患病率和危险因素知之甚少。

设计： 

在泰国，对年龄大于50岁（N = 298）的PLHIV进行了抗逆转录病毒治疗（ART）和HIV阴性对照（N = 100）频率的横断面研究。

方法： 

所有参加者均接受由训练有素的心脏病专家进行的标准二维经胸超声心动图检查，而他们对参加者的护理和HIV状况视而不见。Logistic回归用于检查心脏异常与危险因素之间的关联。

结果： 

中位年龄为54.7岁（男性为60.8％），其中高血压为37.2％，糖尿病为16.6％。PLHIV接受ART治疗的中位数为16.2年，目前CD4细胞计数为616个细胞/立方毫米。超声心动图异常在PLHIV（55％）和对照组（60％）之间没有差异。PLHIV的主要异常如下：左心室肥大：男性37％，女性42.2％，左室收缩功能障碍（0.7％），舒张功能障碍（24.2％）和肺动脉高压（3.9％）。根据PLHIV的多变量分析，年龄> 60岁与舒张功​​能障碍独立相关，而女性和左心房容积指数> 34 mL / m ²与肺动脉高压相关（P<0.05）。没有任何ART与任何重大超声心动图异常显着相关。

结论： 

在这个长期受压制的，老年的亚洲PLHIV队列中，无症状LV收缩功能障碍和肺动脉高压的患病率相对较低，而舒张功能障碍和LV肥大则很常见。感染者和未感染艾滋病毒的对照组之间的超声心动图检查结果无差异。