Abstract

Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration of compounds 2–6 has been revised. The major isolates were tested for cytotoxic activity against HeLa human cervical cancer cells, and all showed moderate activities.

中文翻译：

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从Sedum sarmentosum Bunge中分离出的巨柱石的化学成分和绝对构型

摘要

对从越南采集的景天属植物的甲醇提取物进行植物化学研究，结果分离出一种新的巨豆苷，名为景天苷 K ( 1 )，以及 17 种先前报道的化合物 ( 2-18 )。通过 HRFABMS、NMR 光谱分析、酸水解和量子 ECD 计算实现了新化合物的结构解析。化合物2-6的绝对构型已被修改。对主要分离株进行了针对 HeLa 人宫颈癌细胞的细胞毒活性测试，均显示出中等活性。