Synthesis of 3,4-Functionalized Benzothiazines through C−H Activation,Israel Journal of Chemistry

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Synthesis of 3,4-Functionalized Benzothiazines through C−H Activation
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2020-10-20 , DOI: 10.1002/ijch.202000074
Jeong‐Yu Son ₁ , Da‐Hye Jeon ₁ , Haeun Jang ₁ , Phil Ho Lee _{1,

2}

Affiliation

A method for the synthesis of a wide range of 1,2-benzothiazines bearing pyridyl, amide, sulfonamide, alkenyl, as well as aryl groups in 3,4-position has been developed using transition metal-catalyzed C−H activation reactions of pyridylbenzothiazines with dioxazolones, tosyl azide, alkenes, alkynes, and diaryliodonium salts. The present reaction provides an efficient method for the synthesis of a variety of 3,4-functionalized benzothiazines from readily available starting materials and benefits a broad substrate scope, high functional group tolerance, and good regioselectivity.

中文翻译：

通过 C−H 活化合成 3,4-功能化苯并噻嗪

使用过渡金属催化的吡啶基苯并噻嗪的 C-H 活化反应，开发了一种合成广泛的 1,2-苯并噻嗪的方法，该方法在 3,4-位带有吡啶基、酰胺、磺酰胺、烯基和芳基与二恶唑酮、甲苯磺酰叠氮化物、烯烃、炔烃和二芳基碘鎓盐。本反应提供了一种从易得的起始材料合成各种 3,4-官能化苯并噻嗪的有效方法，并具有广泛的底物范围、高官能团耐受性和良好的区域选择性。

更新日期：2020-10-20

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