Emerging Strategies in Anticancer Combination Therapy Employing Silica‐Based Nanosystems,Biotechnology Journal

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Emerging Strategies in Anticancer Combination Therapy Employing Silica‐Based Nanosystems
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-10-20 , DOI: 10.1002/biot.201900438
Rafael R. Castillo _{1,

2,

3} , Maria Vallet‐Regí _{1,

2,

3}

Affiliation

Combination therapy has emerged as one of the most promising approaches for cancer treatment. However, beyond remotely‐triggered therapies that require advanced infrastructures and optimization, new combination therapies based on internally triggered cell‐killing effects have also demonstrated promising therapeutic profiles. In this revision, the focus is on self‐triggered strategies able to improve the therapeutic effect of drug delivery nanosystems. As reviewed, ferroptosis, hypoxia, and immunotherapy show potency enough to treat satisfactorily tumors in vivo. However, the interest of combining those with chemotherapeutics, especially with carriers based on mesoporous silica, has provided a new generation of therapeutic nanomedicines with potential enough to achieve complete tumor remission in murine models.

中文翻译：

基于二氧化硅的纳米系统在抗癌联合疗法中的新兴策略

组合疗法已成为最有前途的癌症治疗方法之一。但是，除了需要先进的基础设施和优化的远程触发疗法外，基于内部触发的细胞杀伤作用的新组合疗法也显示出了令人鼓舞的疗法。在本修订版中，重点是能够提高药物递送纳米系统治疗效果的自触发策略。综上所述，肥大症，低氧和免疫疗法显示出足以在体内令人满意地治疗肿瘤的潜能。然而，将它们与化学疗法特别是与基于中孔二氧化硅的载体组合的兴趣提供了新一代的治疗性纳米药物，其潜力足以在鼠模型中实现完全的肿瘤缓解。

更新日期：2020-10-20

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