Cell‐mediated and humoral adaptive immune responses to SARS‐CoV‐2 are lower in asymptomatic than symptomatic COVID‐19 patients,European Journal of Immunology

当前位置： X-MOL 学术 › Eur. J. Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cell‐mediated and humoral adaptive immune responses to SARS‐CoV‐2 are lower in asymptomatic than symptomatic COVID‐19 patients
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-10-20 , DOI: 10.1002/eji.202048915
Alessio Mazzoni ₁ , Laura Maggi ₁ , Manuela Capone ₁ , Michele Spinicci _{1,

2} , Lorenzo Salvati ₁ , Maria Grazia Colao ₃ , Anna Vanni ₁ , Seble Tekle Kiros ₃ , Jessica Mencarini _{1,

2} , Lorenzo Zammarchi _{1,

2} , Elisabetta Mantengoli ₂ , Lorenzo Menicacci ₁ , Eleonora Caldini ₁ , Sergio Romagnani ₁ , Francesco Liotta _{1,

4} , Alessandro Morettini ₅ , Gian Maria Rossolini _{1,

3} , Alessandro Bartoloni _{1,

2} , Lorenzo Cosmi _{1,

4} , Francesco Annunziato _{1,

6}

Affiliation

The characterization of cell‐mediated and humoral adaptive immune responses to SARS‐CoV‐2 is fundamental to understand COVID‐19 progression and the development of immunological memory to the virus. In this study, we detected T‐cells reactive to SARS‐CoV‐2 proteins M, S, and N, as well as serum virus‐specific IgM, IgA, IgG, in nearly all SARS‐CoV‐2 infected individuals, but not in healthy donors. Virus‐reactive T cells exhibited signs of in vivo activation, as suggested by the surface expression of immune‐checkpoint molecules PD1 and TIGIT. Of note, we detected antigen‐specific adaptive immune response both in asymptomatic and symptomatic SARS‐CoV‐2 infected subjects. More importantly, symptomatic patients displayed a significantly higher magnitude of both cell‐mediated and humoral adaptive immune response to the virus, as compared to asymptomatic individuals. These findings suggest that an uncontrolled adaptive immune response contribute to the development of the life‐threatening inflammatory phase of the disease. Finally, this study might open the way to develop effective vaccination strategies.

中文翻译：

无症状患者对SARS‐CoV‐2的细胞介导和体液适应性免疫反应低于有症状的COVID‐19患者

表征SARS‐CoV‐2的细胞介导和体液适应性免疫反应是了解COVID‐19进展和对该病毒的免疫记忆的基础。在这项研究中，我们几乎在所有感染SARS-CoV-2的个体中检测到对SARS-CoV-2蛋白M，S和N有反应性的T细胞，以及血清病毒特异性IgM，IgA，IgG在健康的捐助者中。病毒反应性T细胞表现出体内活化的迹象，免疫检查点分子PD1和TIGIT的表面表达表明了这一点。值得注意的是，我们在无症状和有症状的SARS-CoV-2感染者中检测到抗原特异性适应性免疫反应。更重要的是，有症状的患者对病毒的细胞介导和体液适应性免疫反应均显着增强，与无症状的个体相比。这些发现表明，不受控制的适应性免疫反应可导致疾病威胁生命的炎症阶段的发展。最后，这项研究可能为开发有效的疫苗接种策略开辟道路。

更新日期：2020-12-11

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11