Lung cancer is the leading cause of cancer‐related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs. Here, we review the current knowledge of the epigenetic regulation of angiogenesis and discuss the potential clinical applications of epigenetic‐based anticancer therapy in lung cancer. Overall, epigenetic‐based therapy will likely emerge as a prominent approach to treat lung cancer in the future.

中文翻译：

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肺癌血管生成的表观遗传调控

肺癌是全球癌症相关死亡的主要原因，其中肺癌细胞的生长和转移非常需要血管生成。这种多步骤过程的遗传调控正在被广泛研究，然而，对肺癌血管生成的表观遗传调控的了解相对较少。一些表观遗传改变有助于调节血管生成，例如 DNA 的表观修饰、组蛋白的翻译后修饰和非编码 RNA 的表达。在这里，我们回顾了血管生成表观遗传调控的现有知识，并讨论了基于表观遗传的抗癌治疗在肺癌中的潜在临床应用。总体而言，基于表观遗传的治疗可能会成为未来治疗肺癌的主要方法。