JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps,Human Brain Mapping

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JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-20 , DOI: 10.1002/hbm.25244
Juergen Dukart _{1,

2} , Stefan Holiga ₃ , Michael Rullmann ₄ , Rupert Lanzenberger ₅ , Peter C T Hawkins ₆ , Mitul A Mehta ₆ , Swen Hesse ₄ , Henryk Barthel ₄ , Osama Sabri ₄ , Robert Jech ₇ , Simon B Eickhoff _{1,

2}

Affiliation

Recent studies have shown that drug‐induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (rsfMRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a toolbox (JuSpace) allowing for cross‐modal correlation of MRI‐based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, and GABAergic (gamma‐aminobutric acid) neurotransmission. We apply JuSpace to two datasets covering Parkinson's disease patients (PD) and risperidone‐induced changes in rsfMRI and cerebral blood flow (CBF). Consistently with the predominant neurodegeneration of dopaminergic and serotonergic system in PD, we find significant spatial associations between rsfMRI activity alterations in PD and dopaminergic (D2) and serotonergic systems (5‐HT1b). Risperidone induced CBF alterations were correlated with its main targets in serotonergic and dopaminergic systems. JuSpace provides a biologically meaningful framework for linking neuroimaging to underlying neurotransmitter information.

中文翻译：

JuSpace：使用核成像衍生的神经递质图对磁共振成像数据进行空间相关性分析的工具

最近的研究表明，使用磁共振成像 (rsfMRI) 测量的静息状态功能活动中药物诱导的空间改变模式与各个化合物靶向的特定受体系统的分布有关。基于这种方法，我们引入了一个工具箱 (JuSpace)，允许基于 MRI 的测量与核成像衍生估计的跨模式关联，涵盖各种神经递质系统，包括多巴胺能、5-羟色胺能、去甲肾上腺素能和 GABA 能（γ-氨基丁酸）神经传递。我们将 JuSpace 应用于涵盖帕金森病患者 (PD) 和利培酮引起的 rsfMRI 和脑血流量 (CBF) 变化的两个数据集。与 PD 中多巴胺能和血清素能系统的主要神经变性一致，我们发现 PD 与多巴胺能 (D2) 和血清素能系统 (5-HT1b) 的 rsfMRI 活性改变之间存在显着的空间关联。利培酮诱导的 CBF 改变与其在血清素能和多巴胺能系统中的主要目标相关。JuSpace 提供了一个具有生物学意义的框架，用于将神经影像与潜在的神经递质信息联系起来。

更新日期：2020-10-20

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