Numerical and Experimental Biomass Separation from Fermentation Process by Minihydrocyclones,Chemical Engineering & Technology

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Numerical and Experimental Biomass Separation from Fermentation Process by Minihydrocyclones
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-10-20 , DOI: 10.1002/ceat.202000130
Laleh Abdollahzadeh ₁ , Masoumeh Seyfi Mazraeno ₂ , Seyed Nezamedin Hosseini ₁ , Alireza Fazlali ₂ , Ehsan Soury ₂ , Mahmoud Habibian ₃ , Maryam Khatami ₁

Affiliation

Biomass particle separation is challenging in the pharmaceutical industry because of the smallness and lightness of such particles. Centrifugation is applied conventionally for batch separation. However, imposing multiple wash steps in order to eliminate culture residues and the high risk of extrinsic contamination hamper batch techniques. In this research, minihydrocyclones were introduced to provide a better solution for the mentioned limitations in continuous processes. Numerical separation of methylotrophic yeast from fermentation broth was carried out in three hydrocyclones with different lengths, and the most efficient one was examined experimentally. Three various feed flow rates and seven feed concentrations were evaluated. The concentration of biomass suspension in the product was raised to 20 %.

中文翻译：

微型旋风分离器从发酵过程中分离出的数值和实验生物质

生物质颗粒的分离在制药工业中具有挑战性，因为此类颗粒的体积小且重量轻。离心通常用于批量分离。但是，采用多个洗涤步骤以消除培养残留物和外部污染的高风险阻碍了分批技术。在这项研究中，引入了微型水力旋流器，以为上述连续过程中的局限性提供更好的解决方案。在三个不同长度的水力旋流器中，从发酵液中数值分离了甲基营养酵母，并通过实验研究了最有效的一种。评价了三种不同的进料流速和七个进料浓度。产品中生物质悬浮液的浓度提高到20％。

更新日期：2020-12-14

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