Polyphenol‐Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment,Angewandte Chemie International Edition

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Polyphenol‐Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-10-19 , DOI: 10.1002/anie.202013406
Zhan Zhang ₁ , Wei Sang ₁ , Lisi Xie ₁ , Wenxi Li ₁ , Bei Li ₁ , Jie Li ₁ , Hao Tian ₁ , Zhen Yuan ₁ , Qi Zhao ₁ , Yunlu Dai ₁

Affiliation

Engineering multifunctional nanoplatforms with high therapeutic benefits has become a promising strategy for intractable cancer treatment. A novel polyphenol‐based nanocomplex was designed to evoke highly efficacious cancer immunosurveillance while localizing therapy on the primary tumor and to minimize systemic side effects. This nanocomplex is prepared via metal–polyphenol coordination by encapsulating a natural polyphenol, gossypol, and a newly synthesized polyphenol derivative, polyethylene glycol‐Chlorin e6 (Ce6). The combination of gossypol from cotton and the photosensitizer Ce6 can induce chemotherapeutic/photodynamic immunogenic cancer cell death upon laser irradiation, which is supported by a rich maturation of dendritic cells, concentrated secretion of inflammatory cytokines, and significant inhibition of distant untreated tumors. Finally, an assistance of the programmed‐cell‐death ligand‐1 checkpoint‐blockade immunotherapy can enhance the anti‐tumor immune stimulation of our nanoplatform to a higher level.

中文翻译：

基于多酚的纳米药物引起免疫激活，可用于联合癌症治疗。

设计具有高治疗功效的多功能纳米平台已成为顽固性癌症治疗的有前途的策略。一种新型的基于多酚的纳米复合物旨在唤起高效的癌症免疫监测，同时在原发性肿瘤上进行局部治疗，并将全身性副作用降至最低。通过包裹天然多酚，棉酚和新合成的多酚衍生物聚乙二醇-Chlorin e6（Ce6），通过金属-多酚配位制备这种纳米复合物。棉酚和光敏剂Ce6的组合可在激光照射后诱导化学治疗/光动力免疫原性癌细胞死亡，这由树突状细胞的丰富成熟，炎性细胞因子的集中分泌以及对远处未治疗肿瘤的显着抑制提供支持。

更新日期：2020-10-19

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