Cognitive Processing Therapy (CPT) and Behavioural Activation Therapy (BA) were used to treat individuals with comorbid posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Fifty-two individuals (48 women, 4 men) were randomized to CPT alone (n = 18), CPT then BA for MDD (n = 17), or BA then CPT (n = 17). Presenting trauma was primarily interpersonal (87 %). Participants were assessed at pre-, posttreatment, and 6-month follow-up. PTSD and MDD symptoms were the main outcome of interest; trauma cognitions, rumination, and emotional numbing were secondary outcomes. All groups showed sizeable reductions in PTSD and depression (effect sizes at follow-up ranging between 1.02–2.54). A pattern of findings indicated CPT/BA showed better outcomes in terms of larger effect sizes and loss of diagnoses relative to CPT alone and BA/CPT. At follow-up greater numbers of the CPT/BA group were estimated to have achieved good end-state for remission of both PTSD and depression (49 %, CI₉₅ [.26, .73]) relative to CPT alone (18 %, CI₉₅ [.03, .38]) and BA/CPT (11 %, CI₉₅ [.01, .29]). Although tempered by the modest sample size, the findings suggest that individuals with comorbid PTSD and MDD may benefit from having PTSD targeted first before remaining MDD symptoms are addressed.

认知加工疗法（CPT）和行为激活疗法（BA）用于治疗患有合并症的创伤后应激障碍（PTSD）和重度抑郁症（MDD）的个体。52名个体（48名女性，4名男性）被随机分为CPT（n = 18），CPT然后是MDD的BA（n = 17）或BA然后是CPT（n =17）。创伤主要是人际交往（87％）。在治疗前，治疗后和6个月的随访中对参与者进行评估。PTSD和MDD症状是主要的研究结果。次要结果是创伤认知，反省和情绪麻木。所有组均显示出PTSD和抑郁症的大量减少（随访时的影响范围为1.02-2.54）。结果的模式表明，相对于单独的CPT和BA / CPT，CPT / BA在更大的影响范围和更大的诊断损失方面显示出更好的结局。随访时，相对于单独的CPT（18％，CPT / BA组），PTSD和抑郁症的缓解都达到了良好的最终状态（49％，CI ₉₅ [.26，.73]）。 CI ₉₅ [.03，.38]和BA / CPT（11％，CI ₉₅[.01，.29]）。尽管受到样本量的限制，但发现提示合并PTSD和MDD的患者在解决剩余的MDD症状之前，首先将PTSD靶向可能会受益。