Abstract Poly(β-amino ester)s (PβAE)s are considered as the most potent alternative to viral vectors, which has been increasingly proposed for targeting gene delivery, because of their excellent transfection performance. The self-assembled nanoparticles formed from interaction with nucleic acids showed good biodegradable and hydrophilic nature, which make PβAE superior over other polycationic polymers. PβAEs exhibit different kinetic profiles and tunable charge density, which can be fabricated using a diverse library of building blocks and binding various conjugates to improve transfection efficiency. The rational designing of PβAE is a critical step to achieve various requirements of gene delivery, anticancer and antimicrobial drug delivery, and nanochaperones. This review presents a revised recapitulation of the synthesis protocols, formulation aspects, and biomedical applications of PβAEs. Within each of these titles, a critical analysis of the design principles and strategies along with examples, opportunities, and challenges are discussed.

中文翻译：

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基于聚（β-氨基酯）的潜在药物递送和靶向聚合物；概述和观点（评论）

摘要 聚（β-氨基酯）（PβAE）被认为是病毒载体最有效的替代品，由于其优异的转染性能，越来越多地建议将其用于靶向基因递送。与核酸相互作用形成的自组装纳米粒子显示出良好的可生物降解性和亲水性，这使得 PβAE 优于其他聚阳离子聚合物。PβAEs 表现出不同的动力学特征和可调电荷密度，可以使用不同的构建块库和结合各种缀合物来提高转染效率。PβAE的合理设计是实现基因传递、抗癌和抗菌药物传递以及纳米伴侣的各种要求的关键步骤。本综述对合成方案进行了修订后的概括，PβAE 的制剂方面和生物医学应用。在每个标题中，都讨论了对设计原则和策略的批判性分析以及示例、机会和挑战。