Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections in both community and hospital settings, with high mortality rates. Treatment of MRSA infections is challenging because of the rapidly evolving resistance mechanisms combined with the protective biofilms of S. aureus. Together, these characteristic resistance mechanisms continue to render conventional treatment modalities ineffective. The use of nanoformulations with unique modes of transport across bacterial membranes could be a useful strategy for disease-specific delivery. In this review, we summarize treatment approaches for MRSA, including novel techniques in nanoparticulate designing for better therapeutic outcomes; and facilitate an understanding that nanoparticulate delivery systems could be a robust approach in the successful treatment of MRSA.

耐甲氧西林金黄色葡萄球菌(MRSA) 会在社区和医院环境中引起严重感染，死亡率很高。由于快速发展的耐药机制与金黄色葡萄球菌的保护性生物膜相结合，MRSA 感染的治疗具有挑战性. 总之，这些特征性的抵抗机制继续使传统的治疗方式无效。使用具有独特跨细菌膜运输方式的纳米制剂可能是针对特定疾病的递送的有用策略。在这篇综述中，我们总结了 MRSA 的治疗方法，包括纳米颗粒设计的新技术，以获得更好的治疗效果；并促进理解纳米颗粒递送系统可能是成功治疗 MRSA 的有效方法。