A mild universal method for the synthesis of derivatives of 5-substituted 1H-1,2,4-triazole-3-carboxylic acids from a single precursor, ethyl β-N-Boc-oxalamidrazone, has been proposed. The method was applied for the parallel synthesis of a library of 1H-1,2,4-triazole-3-carboxamides with heterocyclic substituents at position 5.

中文翻译：

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并行合成5位上带有杂环取代基的1 H -1,2,4-三唑-3-羧酸衍生物

已经提出了一种温和的通用方法，该方法可从单一的前体乙基β- N -Boc-草并dra酮合成5个取代的1 H -1,2,4-三唑-3-羧酸的衍生物。该方法适用于1 H -1,2,4-三唑-3-羧酰胺库在5位杂环取代基的平行合成。