Pork-derived products can contribute to the overall ochratoxin A (OTA) intake via carry-over from contaminated feed or via mould spoilage of meat products (salami, dry-cured ham, sausage). An analytical method using liquid chromatography coupled with mass spectrometry (LC-MS/MS) was developed and validated in accordance with the specifications laid down by European Commission. It offered quantification limits of 0.2 for kidney, liver and 0.4 μg/kg for black sausage. Spiking experiments of blank samples at 5–10 μg/kg showed recoveries ranging from 88 to 101%, 89 to 97% and 80 to 85% for kidney, liver and black sausage, respectively. The respective intra-laboratory repeatabilities ranged between 9.8–11.1%, 9.4–14.4% and 9.7–14.2%, and extended measurement uncertainties MU_(k = 2) were 33%, 35% and 43% for kidney, liver and black sausage. Next, the validated method was applied to kidney (110), liver (20) and black sausage (20) samples collected in Belgium in the period 2012–2019. Neither liver nor black sausage samples were contaminated with OTA. Kidney samples (37.3%) were OTA contaminated at the mean level of 0.22 ± 0.25 μg/kg (up to 1.91 μg/kg). These data combined with the offal consumption in the Belgian population revealed average daily OTA exposures ranged from 0.167 and 0.319 ng/kg bw for 3 age groups (3–9, 10–17 and 18–64 years). Taking into account, the OTA non-neoplastic and neoplastic effects, risk characterization assessed via the margin of exposure for reference endpoints revealed no potential health risk for the consumers. As the presence of low OTA content in foods together with other mycotoxins or derivatives may interactively potentiate its toxicity, monitoring of OTA and its metabolites in meat and meat by-products is advised.

猪肉衍生产品可通过污染饲料的残留物或肉制品（意大利腊肠、干腌火腿、香肠）的霉菌变质，增加赭曲霉毒素 A (OTA) 的总摄入量。根据欧盟委员会制定的规范，开发并验证了一种使用液相色谱与质谱联用 (LC-MS/MS) 的分析方法。它提供了 0.2 的肾、肝和 0.4 μg/kg 黑香肠的定量限。空白样品以 5–10 μg/kg 加标实验表明，肾、肝和黑肠的回收率分别为 88% 至 101%、89% 至 97% 和 80% 至 85%。各自的实验室内重复性介于 9.8-11.1%、9.4-14.4% 和 9.7-14.2% 之间，扩展测量不确定度 MU _{( k  = 2)}肾、肝和黑肠分别为 33%、35% 和 43%。接下来，将经过验证的方法应用于 2012-2019 年期间在比利时收集的肾脏 (110)、肝脏 (20) 和黑香肠 (20) 样本。肝脏和黑香肠样品均未受到 OTA 污染。肾脏样本 (37.3%) 被 OTA 污染，平均水平为 0.22 ± 0.25 μg/kg（高达 1.91 μg/kg）。这些数据结合比利时人口的内脏消费显示，3 个年龄组（3-9、10-17 和 18-64 岁）的平均每日 OTA 暴露范围为 0.167 和 0.319 ng/kg bw。考虑到 OTA 非肿瘤和肿瘤效应，通过参考端点的暴露边际评估的风险特征显示，对消费者没有潜在的健康风险。