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Double trouble? Impact of frozen embryo transfer on the monozygotic twinning rate: a retrospective cohort study from 8459 cycles
Journal of Assisted Reproduction and Genetics ( IF 3.2 ) Pub Date : 2020-10-20 , DOI: 10.1007/s10815-020-01985-2
Xitong Liu 1 , Ping Li 1 , Juanzi Shi 1
Affiliation  

Purpose

To compare monozygotic twinning (MZT) rates in patients undergoing fresh embryo transfer (ET) and frozen embryo transfer.

Methods

All clinical pregnancies after single ET carried out in our IVF center between 2014 and 2018 (n = 8459) were retrospectively analyzed for the incidence of MZT. MZT rate was compared in women who underwent fresh ET (n = 3876) and frozen ET (n = 4583).

Results

There was a total of 120 MZT identified in the fresh ET group (3.10%) and 103 MZT in the frozen ET group (2.25%), which was significant (p = 0.015). In the univariate analysis, the risk of MZT was decreased with frozen embryo transfer (OR 0.72; 95% CI, 0.55–0.94, p = 0.016) and increased with mild stimulation protocol in the fresh cycle (OR 1.90; 95% CI, 1.04–3.45, p = 0.036). Multivariable logistic regression revealed that frozen embryo transfer was associated with a significant decrease risk of MZT (adjusted OR 0.66; 95% CI, 0.46–0.90, p = 0.011).

Conclusions

Frozen ET is associated with a lower risk of MZT.



中文翻译:

双重麻烦?冷冻胚胎移植对单卵双胞胎率的影响:一项来自 8459 个周期的回顾性队列研究

目的

比较接受新鲜胚胎移植 (ET) 和冷冻胚胎移植的患者的单卵孪生 (MZT) 率。

方法

 回顾性分析了2014 年至 2018 年间在我们的 IVF 中心(n = 8459)进行的单次 ET 后所有临床妊娠的 MZT 发生率。比较接受新鲜 ET ( n  = 3876) 和冷冻 ET ( n  = 4583) 的女性的 MZT 率。

结果

在新鲜 ET 组 (3.10%) 和冷冻 ET 组 (2.25%) 中总共鉴定出 120 MZT,这是显着的 ( p  = 0.015)。在单变量分析中,冷冻胚胎移植降低了 MZT 的风险(OR 0.72;95% CI,0.55–0.94,p  = 0.016),并在新鲜周期中随着温和刺激方案增加(OR 1.90;95% CI,1.04) –3.45,p  = 0.036)。多变量逻辑回归显示冷冻胚胎移植与 MZT 风险显着降低相关(调整后的 OR 0.66;95% CI,0.46–0.90,p  = 0.011)。

结论

冷冻 ET 与较低的 MZT 风险相关。

更新日期:2020-10-20
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