The p140Cap adaptor protein is a scaffold molecule encoded by the SRCIN1 gene, which is physiologically expressed in several epithelial tissues and in the neurons. However, p140Cap is also strongly expressed in a significant subset of cancers including breast cancer and neuroblastoma. Notably, cancer patients with high p140Cap expression in their primary tumors have a lower probability of developing a distant event and ERBB2-positive breast cancer sufferers show better survival. In neuroblastoma patients, SRCIN1 mRNA levels represent an independent risk factor, which is inversely correlated to disease aggressiveness. Consistent with clinical data, SRCIN1 gain or loss of function mouse models demonstrated that p140Cap may affect tumor growth and metastasis formation by controlling the signaling pathways involved in tumorigenesis and metastatic features. This study reviews data showing the relevance of SRCIN1/p140Cap in cancer patients, the impact of SRCIN1 status on p140Cap expression, the specific mechanisms through which p140Cap can limit cancer progression, the molecular functions regulated by p140Cap, along with the p140Cap interactome, to unveil its key role for patient stratification in clinics.

p140Cap衔接子蛋白是由SRCIN1基因编码的支架分子，在一些上皮组织和神经元中生理表达。但是，p140Cap在包括乳腺癌和神经母细胞瘤在内的多种癌症中也有强烈表达。值得注意的是，在其原发肿瘤中具有高p140Cap表达的癌症患者发生远处事件的可能性较低，而ERBB2阳性乳腺癌患者的生存率更高。在神经母细胞瘤患者中，SRCIN1 mRNA水平是一个独立的危险因素，与疾病的侵袭性呈负相关。与临床数据一致，SRCIN1功能获得或丧失的小鼠模型证明p140Cap可能通过控制参与肿瘤发生和转移特征的信号通路来影响肿瘤的生长和转移的形成。这项研究回顾了显示SRCIN1 / p140Cap在癌症患者中的相关性，SRCIN1状态对p140Cap表达的影响，p140Cap通过其限制癌症进展的特定机制，由p140Cap调节的分子功能以及p140Cap相互作用组的数据，以揭示这些数据。它对临床患者分层的关键作用。