当前位置: X-MOL 学术Ann. Clin. Microbiol. Antimicrob. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Methicillin-resistant Staphylococcus aureus nasal carriage among janitors working in hospital and non-hospital areas: a comparative cross-sectional study
Annals of Clinical Microbiology and Antimicrobials ( IF 4.6 ) Pub Date : 2020-10-19 , DOI: 10.1186/s12941-020-00391-x
Seid Abie , Moges Tiruneh , Wondwossen Abebe

Nasal colonization of Methicillin-resistant Staphylococcus aureus (MRSA) plays a key role in the epidemiology and pathogenesis of both healthcare-associated and community-acquired MRSA infections in various populations. Screening of MRSA nasal colonization is important in the prevention and control of infection and may provide useful information to guide antimicrobial therapy. This study aimed to determine nasal carriage of MRSA, its antimicrobial susceptibility pattern, and associated factors among janitors working in hospital & non-hospital areas at the University of Gondar, Northwest Ethiopia. A comparative cross-sectional study was carried out in a total of 436 study participants (221 hospital and 215 non-hospital janitors) from January to May 2019. The study participants were sampled using a simple random sampling technique. Data on socio-demographic characteristics and associated factors were collected through face to face interviews using a structured questionnaire. Nasal swabs were collected and inoculated into Mannitol salt agar. MRSA was detected using cefoxitin (30 µg) disc and an antibiotic susceptibility test was done using the disc diffusion method. Data were entered and analyzed using SPSS version 20 statistical package. P value ≤ 0.05 was considered as statistically significant. The overall prevalence of S. aureus was 101/436 [23.2%, (95% CI: 19.3–27.8)], of which, 29.4% (65/221) were isolated from hospital and 16.7% (36/215) non-hospital janitors. The prevalence of MRSA was 4.8% (21/436) [95% CI: 3.0–6.9]; of these, 8.1% (18/221) of the isolates were from the hospital and 1.4% (3/215) non-hospital janitors, while methicillin-sensitive S. aureus (MSSA) in hospital & non-hospital janitors were 49 (22.2%) and 31 (14.4%), respectively. Among the MRSA isolates, 52.4% (11/21) were multi-drug resistant. Of these, 42.9% (9/18) were isolated from hospital and 66.7% (2/3) non-hospital janitors. Hence, nasal carriage of MRSA was significantly associated with hospitalization within the preceding year (AOR = 3.15, CI = 1.13–8.71). The present study revealed that high MSSA and MRSA were isolated from the hospital as compared to non-hospital janitors and high rates of antibiotics resistance were recorded in the hospital janitors. Consequently, hospitalizations were significantly associated with MRSA. Accordingly, regular screening of carriers in apparently healthy janitors is required for the prevention of nosocomial infections.

中文翻译:

在医院和非医院区域工作的看门人中耐甲氧西林金黄色葡萄球菌鼻支架的比较横断面研究

耐甲氧西林金黄色葡萄球菌(MRSA)的鼻部定植在各种人群中医疗保健相关和社区获得性MRSA感染的流行病学和发病机理中都起着关键作用。筛查MRSA鼻部定植对预防和控制感染很重要,并且可能提供指导抗菌治疗的有用信息。这项研究的目的是确定埃塞俄比亚西北部贡达尔大学在医院和非医院区域工作的看门人的鼻甲MRSA携带情况,其抗菌药敏模式以及相关因素。从2019年1月至2019年5月,共对436名研究参与者(221名医院和215名非医院看门人)进行了比较性横断面研究。采用简单的随机抽样技术对研究参与者进行抽样。使用结构化问卷通过面对面访谈收集了社会人口学特征和相关因素的数据。收集鼻拭子并接种到甘露醇盐琼脂中。使用头孢西丁(30 µg)椎间盘检测MRSA,并使用椎间盘扩散法进行抗生素敏感性试验。使用SPSS 20版统计软件包输入并分析数据。P值≤0.05被认为具有统计学意义。金黄色葡萄球菌的总体患病率为101/436 [23.2%,(95%CI:19.3–27.8)],其中,有29.4%(65/221)来自医院,有16.7%(36/215)为非金黄色葡萄球菌。医院看门人。MRSA的患病率为4.8%(21/436)[95%CI:3.0–6.9];其中,有8.1%(18/221)的分离物来自医院,有1.4%(3/215)的非医院看门人,而对甲氧西林敏感的S。医院和非医院管理员的金黄色葡萄球菌(MSSA)分别为49(22.2%)和31(14.4%)。在MRSA分离物中,有52.4%(11/21)具有多重耐药性。其中,有42.9%(9/18)来自医院,有66.7%(2/3)是非医院看门人。因此,在前一年内,鼻腔携带MRSA与住院治疗显着相关(AOR = 3.15,CI = 1.13–8.71)。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。4%)。在MRSA分离物中,有52.4%(11/21)具有多重耐药性。其中,有42.9%(9/18)来自医院,有66.7%(2/3)是非医院看门人。因此,在前一年内,鼻腔携带MRSA与住院治疗显着相关(AOR = 3.15,CI = 1.13–8.71)。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。4%)。在MRSA分离物中,有52.4%(11/21)具有多重耐药性。其中,有42.9%(9/18)来自医院,有66.7%(2/3)是非医院看门人。因此,在前一年内,鼻腔携带MRSA与住院治疗显着相关(AOR = 3.15,CI = 1.13–8.71)。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。7%(2/3)非医院管理员。因此,在前一年内,鼻腔携带MRSA与住院治疗显着相关(AOR = 3.15,CI = 1.13–8.71)。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。7%(2/3)非医院管理员。因此,在前一年内,鼻腔携带MRSA与住院治疗显着相关(AOR = 3.15,CI = 1.13–8.71)。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。本研究表明,与非医院看门人相比,从医院中分离出的MSSA和MRSA较高,并且在医院看门人中抗生素耐药率较高。因此,住院与MRSA显着相关。因此,为了预防医院内感染,需要定期检查看似健康的看门人中的携带者。
更新日期:2020-10-19
down
wechat
bug