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Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-10-19 , DOI: 10.1039/d0tb01907k
Wenwen Jiang 1, 2, 3, 4, 5 , Yuzhong Chen 1, 2, 3, 4, 5 , Lin Zhao 1, 2, 3, 4, 5 , Jiaying Xu 1, 2, 3, 4, 5 , Rui Zhao 1, 2, 3, 4, 5 , Michael J. Serpe 6, 7, 8, 9 , Liang Hu 1, 2, 3, 4, 5
Affiliation  

Operation therapy is a common treatment for many cancers, but malignant tumors likely recur and metastasize after surgery, resulting in treatment failure. In this study, we aimed at synthesizing a multifunctional hydrogel patch that features multifunctions for synergistic surgery–photothermal therapy. Our polydopamine nanoparticle (PDA NP)-crosslinked poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) hydrogels undergo several dynamic interactions (e.g., hydrogen bonds, π–π interactions, and imine bonds), which confer high stretchability (∼3430%) and adhesive strength to porcine skin (∼75 kPa) that mimics soft wound tissues. Furthermore, PDA NP incorporation into the hydrogel matrix endows it with photothermal responsivity under 808 nm irradiation. As a proof of concept, our hydrogel system was used to ablate residual tumors in 4T1 tumor-bearing mice models after surgery via photothermal therapy. We find that synergistic operation–photothermal therapy effectively eradicates solid tumors and prevents cancer recurrence in mice. We envision that our work provides an effective synergistic strategy for cancer treatment and offers great potential for clinical applications.

中文翻译:

具有生物启发性的组织相容性水凝胶,可用于协同手术-光热疗法

手术治疗是许多癌症的常见治疗方法,但恶性肿瘤在手术后可能复发并转移,导致治疗失败。在这项研究中,我们旨在合成具有多功能功能的多功能水凝胶贴片,用于协同手术–光热疗法。我们的聚多巴胺纳米颗粒(PDA NP)交联的聚(丙烯酰胺-co -N-(3-氨基丙基)甲基丙烯酰胺)水凝胶经历了几种动态相互作用(例如,氢键,π-π相互作用和亚胺键)具有很高的可拉伸性(约3430%)和对猪皮肤的粘合强度(约75 kPa),可模仿柔软的伤口组织。此外,将PDA NP掺入水凝胶基质可使其在808 nm辐射下具有光热响应性。作为概念的证明,我们的水凝胶系统用于通过光热疗法在手术后消融4T1荷瘤小鼠模型中的残留肿瘤。我们发现,协同操作–光热疗法可有效根除实体瘤并防止小鼠癌症复发。我们认为我们的工作为癌症治疗提供了有效的协同策略,并为临床应用提供了巨大潜力。
更新日期:2020-11-03
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