Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review,Journal of Materials Chemistry B

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Chemical and physical chitosan hydrogels as prospective carriers for drug delivery: a review
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-10-19 , DOI: 10.1039/d0tb01869d
Bingren Tian _{1,

2,

3,

4} , Shiyao Hua _{4,

5,

6,

7} , Yu Tian _{4,

8,

9,

10} , Jiayue Liu _{4,

5,

6,

7}

Affiliation

With the advancement of medical research, the source and preparation of biological materials have gradually attracted attention. Hydrogels prepared from natural polysaccharides have been extensively applied in the medical field. The biocompatibility, excellent degradability and low toxicity of chitosan have favored the use of chitosan hydrogels as prospective carriers for drug delivery. Special chitosan hydrogels that effectively release target drugs based on different environmental stimuli have also been developed. This article reviews recent research progress in the development of chemical and physical chitosan hydrogels for drug delivery. In particular, preparation methods together with the chemical and physical properties of chitosan hydrogels are summarized. We also discuss multiple mechanisms of drug release from chitosan hydrogels. Finally, we highlight the future prospects of chitosan hydrogels in medical research.

中文翻译：

化学和物理壳聚糖水凝胶作为药物输送的潜在载体：综述

随着医学研究的发展，生物材料的来源和制备逐渐受到关注。由天然多糖制备的水凝胶已广泛应用于医学领域。壳聚糖的生物相容性，优异的降解性和低毒性已有利于使用壳聚糖水凝胶作为药物递送的预期载体。还开发了可根据不同环境刺激有效释放目标药物的特殊壳聚糖水凝胶。本文概述了化学和物理壳聚糖水凝胶在药物输送中的最新研究进展。特别地，总结了制备方法以及壳聚糖水凝胶的化学和物理性质。我们还讨论了从壳聚糖水凝胶释放药物的多种机制。最后，

更新日期：2020-11-03

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