Background:

CYP24A1 polymorphisms may affect predisposition of cancer, but the results of published studies remain inconclusive. Therefore, the authors conducted this meta-analysis to more robustly assess relationships between CYP24A1 polymorphisms and the predisposition of cancer by pooling the findings of published studies.

Materials and methods:

A comprehensive literature search of PubMed, Embase, Web of Science, Wanfang, and CNKI was endorsed by the authors to identify eligible studies; 17 studies were finally found to be eligible for pooled meta-analysis.

Results:

The pooled meta-analysis results showed that genotypic frequencies of the rs4809960 polymorphism among cancerous patients and controls of Caucasian ethnicity differed significantly, and genotypic frequencies of the rs6022999 polymorphism among cancerous patients and controls of Asian ethnicity also differed significantly. Moreover, we found that genotypic frequencies of the rs2585428 polymorphism among patients with prostate cancer and controls differed significantly, and genotypic frequencies of the rs6068816 polymorphism among patients with prostate cancer/breast cancer and controls also differed significantly.

Conclusions:

This meta-analysis suggests that the rs4809960 polymorphism may affect the predisposition of cancer in Caucasians, and the rs6022999 polymorphism may affect the predisposition of cancer in Asians. Moreover, the rs2585428 polymorphism may affect the predisposition of prostate cancer, while the rs6068816 polymorphism may affect the predisposition of prostate cancer and breast cancer.

中文翻译：

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CYP24A1 多态性与癌症易感性之间的遗传关联：荟萃分析

背景：

CYP24A1多态性可能会影响癌症的易感性，但已发表的研究结果仍无定论。因此，作者进行了这项荟萃分析，通过汇总已发表研究的结果，更有效地评估CYP24A1多态性与癌症易感性之间的关系。

材料和方法：

作者认可了 PubMed、Embase、Web of Science、万方和 CNKI 的综合文献检索，以确定符合条件的研究；最终发现 17 项研究符合汇总荟萃分析的条件。

结果：

汇总荟萃分析结果显示，rs4809960多态性的基因型频率在癌症患者和高加索族裔对照之间存在显着差异，而rs6022999多态性在癌症患者和亚洲裔对照之间的基因型频率也存在显着差异。此外，我们发现前列腺癌患者和对照组之间rs2585428多态性的基因型频率存在显着差异，前列腺癌/乳腺癌患者和对照组之间rs6068816多态性的基因型频率也存在显着差异。

结论：

该荟萃分析表明，rs4809960 多态性可能影响白种人的癌症易感性，而 rs6022999 多态性可能影响亚洲人的癌症易感性。此外，rs2585428多态性可能影响前列腺癌的易感性，而rs6068816多态性可能影响前列腺癌和乳腺癌的易感性。