Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism,Brain Connectivity

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Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism
Brain Connectivity ( IF 3.4 ) Pub Date : 2020-12-14 , DOI: 10.1089/brain.2020.0785
Una Smailovic ₁ , Thomas Koenig ₂ , Irina Savitcheva ₃ , Konstantinos Chiotis _{1,

4} , Agneta Nordberg _{1,

5} , Kaj Blennow ₆ , Bengt Winblad _{7,

8} , Vesna Jelic _{1,

5}

Affiliation

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.
Clinic for Cognitive Disorders, Karolinska University Hospital-Huddinge, Huddinge, Sweden.
Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry and Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Department of Geriatrics, Karolinska University Hospital, Huddinge, Sweden.

Introduction: The disconnection hypothesis of Alzheimer's disease (AD) is supported by growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively impaired individuals. Brain functional modalities such as [¹⁸F]fluorodeoxyglucose positron-emission tomography ([¹⁸F]FDG-PET) and electroencephalography (EEG) measure different aspects of synaptic functioning, and can contribute to understanding brain connectivity disruptions in AD.

中文翻译：

阿尔茨海默痴呆症和淀粉样蛋白阳性轻度认知障碍的区域断开：脑电图功能连接与脑葡萄糖代谢之间的关联

简介：阿尔茨海默病 (AD) 的断开假设得到了越来越多的神经影像学和神经生理学证据的支持，这些证据表明认知障碍个体的大脑功能连接发生了改变。[¹⁸ F] 氟脱氧葡萄糖正电子发射断层扫描 ([¹⁸ F] FDG-PET) 和脑电图 (EEG)等脑功能模式测量突触功能的不同方面，有助于了解 AD 中的大脑连接中断。

更新日期：2020-12-18

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