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Peptide-Enriched Silk Fibroin Sponge and Trabecular Titanium Composites to Enhance Bone Ingrowth of Prosthetic Implants in an Ovine Model of Bone Gaps
Frontiers in Bioengineering and Biotechnology ( IF 4.3 ) Pub Date : 2020-10-19 , DOI: 10.3389/fbioe.2020.563203
Arianna B. Lovati , Silvia Lopa , Marta Bottagisio , Giuseppe Talò , Elena Canciani , Claudia Dellavia , Antonio Alessandrino , Marco Biagiotti , Giuliano Freddi , Francesco Segatti , Matteo Moretti

Osteoarthritis frequently requires arthroplasty. Cementless implants are widely used in clinics to replace damaged cartilage or missing bone tissue. In cementless arthroplasty, the risk of aseptic loosening strictly depends on implant stability and bone–implant interface, which are fundamental to guarantee the long-term success of the implant. Ameliorating the features of prosthetic materials, including their porosity and/or geometry, and identifying osteoconductive and/or osteoinductive coatings of implant surfaces are the main strategies to enhance the bone-implant contact surface area. Herein, the development of a novel composite consisting in the association of macro-porous trabecular titanium with silk fibroin (SF) sponges enriched with anionic fibroin-derived polypeptides is described. This composite is applied to improve early bone ingrowth into the implant mesh in a sheep model of bone defects. The composite enables to nucleate carbonated hydroxyapatite and accelerates the osteoblastic differentiation of resident cells, inducing an outward bone growth, a feature that can be particularly relevant when applying these implants in the case of poor osseointegration. Moreover, the osteoconductive properties of peptide-enriched SF sponges support an inward bone deposition from the native bone towards the implants. This technology can be exploited to improve the biological functionality of various prosthetic materials in terms of early bone fixation and prevention of aseptic loosening in prosthetic surgery.

中文翻译:

富含肽的丝素海绵和骨小梁钛复合材料在骨间隙的绵羊模型中增强假体植入物的骨向内生长

骨关节炎经常需要关节置换术。非骨水泥植入物在临床上广泛用于替换受损的软骨或缺失的骨组织。在非骨水泥关节置换术中,无菌性松动的风险严格取决于种植体稳定性和骨-种植体界面,这是保证种植体长期成功的基础。改善假体材料的特性,包括它们的孔隙率和/或几何形状,以及识别植入物表面的骨传导和/或骨诱导涂层是增加骨 - 植入物接触表面积的主要策略。在此,描述了一种新型复合材料的开发,该复合材料包括大孔小梁钛与富含阴离子丝心蛋白衍生多肽的丝素蛋白 (SF) 海绵的结合。这种复合材料用于改善羊骨缺损模型中植入物网格的早期骨长入。该复合材料能够使碳酸羟基磷灰石成核并加速驻留细胞的成骨细胞分化,诱导向外的骨骼生长,当在骨整合不良的情况下应用这些植入物时,这一特征尤其重要。此外,富含肽的 SF 海绵的骨传导特性支持从天然骨向植入物的向内骨沉积。该技术可用于改善各种假肢材料的生物学功能,在早期骨固定和预防假肢手术中的无菌性松动方面。该复合材料能够使碳酸羟基磷灰石成核并加速驻留细胞的成骨细胞分化,诱导向外的骨骼生长,这一特征在骨整合不良的情况下应用这些植入物时尤其重要。此外,富含肽的 SF 海绵的骨传导特性支持从天然骨向植入物的向内骨沉积。该技术可用于改善各种假肢材料的生物学功能,在早期骨固定和预防假肢手术中的无菌性松动方面。该复合材料能够使碳酸羟基磷灰石成核并加速驻留细胞的成骨细胞分化,诱导向外的骨骼生长,当在骨整合不良的情况下应用这些植入物时,这一特征尤其重要。此外,富含肽的 SF 海绵的骨传导特性支持从天然骨向植入物的向内骨沉积。该技术可用于改善各种假肢材料的生物学功能,在早期骨固定和预防假肢手术中的无菌性松动方面。富含肽的 SF 海绵的骨传导特性支持从天然骨向植入物的向内骨沉积。该技术可用于改善各种假肢材料的生物学功能,在早期骨固定和预防假肢手术中的无菌性松动方面。富含肽的 SF 海绵的骨传导特性支持从天然骨向植入物的向内骨沉积。该技术可用于改善各种假肢材料的生物学功能,在早期骨固定和预防假肢手术中的无菌性松动方面。
更新日期:2020-10-19
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