Adipocyte fatty acid binding protein (A-FABP) is predictive of type 2 diabetes mellitus incidences and metabolic syndrome and is independently associated with atherosclerosis. The present study aimed to assess the association between serum A-FABP levels and future first hospitalization events in kidney transplantation (KT). We enrolled 72 KT patients from January through April 2012 and followed up on these subjects until June 2017. The first hospitalization events incidence was the primary endpoint. Using a commercially available enzyme immunoassay, serum A-FABP levels were measured from the patient’s fasting blood samples. During a median 65-month follow-up, 49 first hospitalization events occurred. KT patients with first hospitalization events had greater incidences of hypertension, diabetes, and higher serum blood urea nitrogen, creatinine, triglyceride, and A-FABP levels than those without the events. Kaplan–Meier analysis showed that the cumulative incidence of first hospitalization events was greater in the high A-FABP group than in the low A-FABP group. Multivariate Cox analysis with significant variables showed that serum A-FABP (hazard ratio = 1.012; 95% confidence interval = 1.000–1.025; p = 0.044) was independently associated with first hospitalization events among KT patients. The results revealed that serum A-FABP is associated with first hospitalization events in KT patients. However, further prospective studies are needed to determine the mechanisms underlying this association.

中文翻译：

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肾移植患者高血清脂肪细胞脂肪酸结合蛋白与首次住院之间的关联：5年随访研究

脂肪细胞脂肪酸结合蛋白（A-FABP）可预测2型糖尿病的发病率和代谢综合征，并且与动脉粥样硬化独立相关。本研究旨在评估血清A-FABP水平与肾脏移植（KT）未来首次住院事件之间的关联。我们从2012年1月至2012年4月招募了72名KT患者，并对这些患者进行了随访，直到2017年6月。首次住院事件的发生是主要终点。使用市售的酶免疫测定法，从患者的空腹血样中测量血清A-FABP水平。在平均65个月的随访期间，发生了49例首次住院事件。首次住院的KT患者高血压，糖尿病的发生率较高，血清尿素氮，肌酐，甘油三酯和A-FABP的水平要比那些没有事件的人高。Kaplan–Meier分析显示，高A-FABP组的首次住院事件累积发生率高于低A-FABP组。带有显着变量的多变量Cox分析表明，血清A-FABP（危险比= 1.012； 95％置信区间= 1.000–1.025；正态分布= 1.000-1.025；p = 0.044）与KT患者中的首次住院事件独立相关。结果表明，血清A-FABP与KT患者的首次住院事件有关。但是，需要进一步的前瞻性研究来确定这种关联的基础机制。