Hyperbaric oxygen therapy (HBOT) is widely used to treat several pathologies. The hemodynamic changes during HBOT, particularly the magnitude of arterial blood pressure (ABP) increase, are not completely understood. No clinical predictors for HBOT-induced ABP increase have been described. The purpose of this study was to quantify ABP changes in patients undergoing HBOT and to examine their predictors. This retrospective longitudinal cohort study examined 3291 elective HBOT sessions. Non-invasive ABP was recorded before and after each session. The primary outcome was to quantify the HBOT-induced ABP rise. The secondary outcome was to determine the ABP-rise predictors among demographic and clinical variables. Overall, ABP increased significantly after HBOT; this finding was more evident in the hypertensive subgroup compared to the normotensive one (+6 vs. +16.2 mmHg). Clinical predictors of significant post-HBOT ABP change were history of hypertension and pre-session baseline ABP classification. This study demonstrates an absolute HBOT-induced ABP rise. This change is clinically relevant in patients with history of hypertension. A higher baseline ABP seems a risk factor for clinically relevant ABP change. Pre-session ABP should be used clinically as an indicator for strict ABP monitoring during HBOT; future studies are recommended to explore the ABP optimization before starting an HBO treatment.

中文翻译：

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高压氧治疗患者血压变化的幅度和临床预测指标：一项回顾性研究

高压氧疗法（HBOT）被广泛用于治疗多种病理。HBOT期间的血流动力学变化，特别是动脉血压（ABP）升高的幅度，尚不完全清楚。尚未描述HBOT诱导的ABP升高的临床预测指标。这项研究的目的是量化接受HBOT的患者的ABP变化并检查其预测因素。这项回顾性纵向队列研究检查了3291项HBOT选择性课程。每次治疗前后均记录无创ABP。主要结果是量化HBOT引起的ABP升高。次要结果是确定人口统计学和临床​​变量中ABP升高的预测因子。总体而言，HBOT后ABP显着增加；与正常血压组相比，这一发现在高血压亚组中更为明显（+6 vs. +16.2 mmHg）。HBOT后ABP发生明显改变的临床预测因素是高血压病史和疗前基线ABP分类。这项研究证明了HBOT引起的绝对ABP升高。这种变化在有高血压病史的患者中具有临床意义。较高的基线ABP似乎是临床相关ABP改变的危险因素。术前ABP在临床上应作为HBOT期间严格ABP监测的指标；建议未来的研究在开始HBO治疗之前探索ABP优化。这种变化在有高血压病史的患者中具有临床意义。较高的基线ABP似乎是临床相关ABP改变的危险因素。术前ABP在临床上应作为HBOT期间严格ABP监测的指标；建议未来的研究在开始HBO治疗之前探索ABP优化。这种变化在有高血压病史的患者中具有临床意义。较高的基线ABP似乎是临床相关ABP改变的危险因素。术前ABP在临床上应作为HBOT期间严格ABP监测的指标；建议未来的研究在开始HBO治疗之前探索ABP优化。