The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of the protein quality control as central factors. In the heart, loss of protein patency, due to flaws in design (genetically) or environmentally-induced wear and tear, may overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac disease onset.

中文翻译：

---

蛋白质稳态脱轨在心脏疾病中的作用

由于人口老龄化和生活方式的改变，心脏病的发病率和患病率是全球范围内的主要死亡原因，可能会增加。关于心脏病发病机制的流行理论以细胞蛋白质稳态（蛋白稳态）的逐渐脱轨和蛋白质质量控​​制的丧失为中心因素。在心脏中，由于设计缺陷（遗传上）或环境导致的磨损而导致的蛋白质通畅性丧失，可能使蛋白质质量控​​制不堪重负，从而触发蛋白稳态脱轨并导致心脏病发作。