Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants.

中文翻译：

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心律失常慢性代谢应激的机制

心律失常是全球许多心血管疾病相关死亡的原因。虽然心律失常的发病机制很复杂，但越来越多的证据表明代谢原因。肥胖、糖尿病和长期食用高脂肪食物会显着增加发生心律失常的可能性。尽管这些相关性已经确立，但将高脂肪饮食 (HFD) 与心律失常联系起来的机制解释是不完整的，尽管氧化应激似乎很关键。这篇综述调查了肥胖和 HFD 后发生的代谢变化。讨论了预防或治疗心律失常的潜在疗法，包括抗氧化剂。