By using Rh-H catalysis, we couple α-nitroesters and alkynes to prepare α-amino acid surrogates. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne undergoes isomerization to generate a Rh(III)-π-allyl electrophile, which is trapped by an α-nitroester nucleophile. A subsequent reduction with In powder transforms the allylic α-nitroesters to the corresponding α,α- disubstituted α-amino esters.

中文翻译：

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硝基酯和炔烃的对映选择性偶联

通过使用Rh-H催化，我们将α-硝基酸酯和炔烃偶联以制备α-氨基酸替代物。这种原子经济策略产生两个连续的立体中心，具有高对映和非对映控制。在这种转化中，炔烃进行异构化生成Rh（III）-π-烯丙基亲电试剂，该亲电子试剂被α-硝基酯亲核试剂捕获。随后用In粉末还原将烯丙基α-硝基酯转化为相应的α，α-二取代的α-氨基酯。