ABSTRACT

Coloading and codelivery of hydrophilic and hydrophobic drugs as techniques for effective therapy have drawn attention but still present a challenge owing to the opposite nature of both drugs. Therefore, determining a convenient method for coloading and coreleasing hydrophilic and hydrophobic drugs in the development of biomedical devices is important. We constructed multilayer films with a microporous structure for the successful coloading of hydrophilic and hydrophobic drugs. The multilayer films were fabricated using chitosan (CS) and polyacrylic acid (PAA) via layer-by-layer self-assembly. A quartz crystal microbalance (QCM) was used to investigate the self-assembly of (CS/PAA) in films. With a low pH to change the inner structure of the multilayer films, these microporous structures exhibit humidity responsiveness and can return to the original compact structures by treatment with 100% relative humidity. The microporous films can simultaneously load a large number of hydrophobic drugs (tetracycline) and hydrophilic model drugs (Rhodamine B) by wicking and subsequent micropore self-healing. The loading and release ratio of the two drugs in the microporous films is consistent with the initial loading ratio in the solution, providing a good platform for coloading and codelivery of hydrophobic and hydrophilic drugs in biomedical applications.

摘要

作为有效疗法的技术，亲水性和疏水性药物的共载和共递送引起了人们的注意，但是由于两种药物的相反性质，仍然提出了挑战。因此，在生物医学设备的开发中，确定一种方便的方法可以共同装载和释放亲水性和疏水性药物很重要。我们构建了具有微孔结构的多层膜，以成功地共载亲水性和疏水性药物。使用壳聚糖（CS）和聚丙烯酸（PAA）通过逐层自组装来制造多层膜。石英晶体微量天平（QCM）用于研究薄膜中（CS / PAA）的自组装。在低pH值下可以改变多层膜的内部结构，这些微孔结构表现出对湿度的响应性，并且可以通过用100％相对湿度进行处理而恢复为原始的紧凑结构。微孔膜可通过芯吸作用和随后的微孔自愈作用，同时装载大量疏水性药物（四环素）和亲水性模型药物（若丹明B）。两种药物在微孔膜中的负载和释放率与溶液中的初始负载率一致，从而为生物医学应用中疏水和亲水药物的共负载和共释放提供了一个良好的平台。