ABSTRACT

N6-methyladenosine (m6A), the most prevalent RNA internal modification, is present in most eukaryotic species and prokaryotes. Studies have highlighted an intricate network architecture by which m6A epitranscriptome impacts on immune response and function. However, it was only until recently that the mechanisms underlying the involvement of m6A modification in immune system were uncovered. Here, we systematically review the m6A involvement in the regulation of innate and adaptive immune cells. Further, the interplay between m6A modification and anti-inflammatory, anti-viral and anti-tumour immunity is also comprehensively summarized. Finally, we focus on the future prospects of m6A modification in immune modulation. A better understanding of the crosstalk between m6A modification and immune system is of great significance to reveal new pathogenic pathways and to develop promising therapeutic targets of diseases.

摘要

N6-甲基腺苷 (m6A) 是最普遍的 RNA 内部修饰，存在于大多数真核生物和原核生物中。研究强调了一个复杂的网络结构，m6A 表观转录组通过该结构影响免疫反应和功能。然而，直到最近才揭示了 m6A 修饰参与免疫系统的机制。在这里，我们系统地回顾了 m6A 参与调节先天性和适应性免疫细胞的过程。此外，还全面总结了m6A修饰与抗炎、抗病毒和抗肿瘤免疫的相互作用。最后，我们关注 m6A 修饰在免疫调节中的未来前景。