ABSTRACT

In this study, the level of serum anti-angiotensin II type 1 receptor autoantibodies (AT1-AA) was determined. It was found that the positive rate of AT1-AA in serum of infertile women is higher than that of healthy non-pregnant women. Spearman correlation analysis showed that AT1-AA was negatively correlated with oocyte maturation rate (r = −0.29, P < 0.01) and AT1-AA was positively correlated with IL-6 (r = 0.68, P < 0.01). Logistic regression analysis showed that age, BMI, type of infertility, years of infertility, history of poor pregnancy outcome, condition of fallopian tube, and polycystic ovary syndrome were not factors influencing the level of AT1-AA in the serum of infertile patients. The results indicated that AT1-AA was involved in the pathological changes of infertile women. AT1-AA may be related to oocyte maturation disorder, ovulation disorder. Interestingly it appears to induce an inflammatory reaction, although the specific mechanism is not clear. However, the level of AT1-AA is not affected by individual differences in infertile patients.

Abbreviations: E₂:estradiol; P:progesterone; RAS:Renin-angiotensin system; Ovras:renin-angiotensin system; ACE1:angiotensin-converting enzyme-1; AngII:angiotensin II; AT1R:Angiotensin II type 1 Receptor; BMI:Body Mass Index; AT1-A:anti-angiotensin II type 1 receptor autoantibodies.

摘要

在本研究中，测定了血清抗血管紧张素 II 1 型受体自身抗体 (AT1-AA) 的水平。发现不孕女性血清中AT1-AA的阳性率高于健康非妊娠女性。Spearman相关分析显示AT1-AA与卵母细胞成熟率呈负相关（r=-0.29，P<0.01），AT1-AA与IL-6呈正相关（r=0.68，P<0.01）。Logistic回归分析显示，年龄、BMI、不孕类型、不孕年限、不良妊娠史、输卵管状况、多囊卵巢综合征均不是影响不孕患者血清AT1-AA水平的因素。结果表明AT1-AA参与了不孕妇女的病理变化。AT1-AA可能与卵母细胞成熟障碍有关，排卵障碍。有趣的是，它似乎会诱发炎症反应，但具体机制尚不清楚。但AT1-AA水平不受不孕患者个体差异的影响。

缩写：E ₂：雌二醇；P：孕酮；RAS：肾素-血管紧张素系统；OVRAS：肾素-血管紧张素系统；ACE1：血管紧张素转化酶-1；AngII：血管紧张素II；AT1R：血管紧张素 II 1 型受体；BMI：体重指数；AT1-A：抗血管紧张素 II 1 型受体自身抗体。