Per‐ and polyfluoroalkyl substances (PFAS) have emerged as contaminants of global concern. Among several PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent and bioaccumulative compounds. We investigated the cyto‐genotoxic potential of PFOS to Allium cepa root meristem cells. The A. cepa root tips were exposed to 6 different concentrations (1–100 mg L⁻¹) of PFOS for 48 h. Reduction in mitotic index and chromosomal aberrations was measured as genotoxic endpoints in meristematic root cells. Exposure to PFOS significantly affected cell division by reducing the miotic index at higher concentrations (>10 mg L⁻¹). The median effect concentration of PFOS to elicit cytotoxicity based on the mitotic index was 43.2 mg L⁻¹. Exposure to PFOS significantly increased chromosomal aberrations at concentrations >25 mg L⁻¹. The common aberrations were micronuclei, vagrant cells, and multipolar anaphase. The alkaline comet assay revealed a genotoxic potential of PFOS with increased tail DNA percentage at concentrations >25 mg L⁻¹. To our knowledge, this is the first study to report the cyto‐genotoxic potential of PFOS in higher plants. Environ Toxicol Chem 2021;40:792–798. © 2020 SETAC

中文翻译：

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全氟辛烷磺酸 (PFOS) 对洋葱的细胞遗传毒性评价

全氟和多氟烷基物质 (PFAS) 已成为全球关注的污染物。在几种 PFAS 中，全氟辛酸 (PFOA) 和全氟辛烷磺酸 (PFOS) 是持久性和生物累积性化合物。我们研究了全氟辛烷磺酸对洋葱根分生组织细胞的细胞遗传毒性潜力。的圆葱根尖暴露于6个不同浓度（1-100毫克的L ^-1全氟辛烷磺酸）48小时。有丝分裂指数和染色体畸变的减少被测量为分生组织根细胞中的遗传毒性终点。暴露于 PFOS 通过降低较高浓度（>10 mg L ^-1）。根据有丝分裂指数，PFOS 引起细胞毒性的中位效应浓度为 43.2 mg L ^-1。PFOS 暴露在浓度 >25 mg L ^{-1 时}显着增加了染色体畸变。常见的畸变是微核、流浪细胞和多极后期。碱性彗星试验揭示了 PFOS 的遗传毒性潜力，在浓度 >25 mg L ^{-1 时}尾部 DNA 百分比增加。据我们所知，这是第一项报告全氟辛烷磺酸在高等植物中的细胞遗传毒性潜力的研究。环境毒理学化学2021；40：792-798。© 2020 SETAC