Microfluidic Assisted Flash Precipitation of Photocrosslinkable Fluorescent Organic Nanoparticles for Fine Size Tuning and Enhanced Photoinduced Processes,ChemPhysChem

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Microfluidic Assisted Flash Precipitation of Photocrosslinkable Fluorescent Organic Nanoparticles for Fine Size Tuning and Enhanced Photoinduced Processes
ChemPhysChem ( IF 2.3 ) Pub Date : 2020-10-19 , DOI: 10.1002/cphc.202000633
Stéphane Hoang ₁ , Simon Olivier _{1,

2} , Stéphane Cuenot ₃ , Agnès Montillet ₄ , Jérôme Bellettre ₅ , Eléna Ishow ₁

Affiliation

Highly concentrated dispersions of fluorescent organic nanoparticles (FONs), broadly used for optical tracking, bioimaging and drug delivery monitoring, are obtained using a newly designed micromixer chamber involving high impacting flows. Fine size tuning and narrow size distributions are easily obtained by varying independently the flow rates of the injected fluids and the concentration of the dye stock solution. The flash nanoprecipitation process employed herein is successfully applied to the fabrication of bicomposite FONs designed to allow energy transfer. Considerable enhancement of the emission signal of the energy acceptors is promoted and its origin is found to result from polarity rather than steric effects. Finally, we exploit the high spatial confinement encountered in FONs and their ability to encapsulate hydrophobic photosensitizers to induce photocrosslinking. An increase in the photocrosslinked FON stiffness is evidenced by measuring the elastic modulus at the nanoscale using atomic force microscopy. These results pave the way toward the straightforward fabrication of multifunctional and mechanically photoswitchable FONs, opening novel opportunities in sensing, multimodal imaging, and theranostics.

中文翻译：

光可交联的荧光有机纳米粒子的微流辅助闪光沉淀，用于精细尺寸调节和增强的光诱导过程

荧光有机纳米颗粒（FONs）的高度浓缩分散体，广泛用于光学跟踪，生物成像和药物输送监控，是使用一种新设计的涉及高冲击流的微混合器腔室获得的。通过独立改变注入流体的流速和染料储备溶液的浓度，可以轻松实现精细的尺寸调整和狭窄的尺寸分布。本文采用的快速纳米沉淀工艺已成功应用于设计成允许能量转移的双复合材料FON。促进了能量受体发射信号的显着增强，并且发现其起源是由于极性而不是空间效应引起的。最后，我们利用FON中遇到的高空间限制及其封装疏水性光敏剂以诱导光交联的能力。通过使用原子力显微镜在纳米级测量弹性模量，可以证明光交联FON刚度的增加。这些结果为直接制造多功能且可机械光切换的FON铺平了道路，为传感，多峰成像和诊断学打开了新的机遇。

更新日期：2020-12-02

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