698

Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment

Elham Gholipour, Parisa Sarvarian, Parisa Samadi, Mehdi Talebi, Aliakbar Movassaghpour, Roza Motavalli, Mohammad Hojjat‐Farsangi and Mehdi Yousefi

Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of exosomes in immune response toward leukemic cells makes them efficient immunotherapeutic agents treating leukemia. Furthermore, variations in exosomes contents make them beneficial to be used in treating different diseases. This review introduces the role of exosomes in the development of hematological malignancies and evaluates their functional role in the treatment of these malignancies.

698

外泌体：从白血病进展到白血病治疗的新治疗方法

Elham Gholipour，Parisa Sarvarian，Parisa Samadi，Mehdi Talebi，Aliakbar Movassaghpour，Roza Motavalli，Mohammad Hojjat-Farsangi和Mehdi Yousefi

外来体作为小囊泡，由肿瘤细胞和肿瘤微环境（细胞和功能作为关键的细胞间介体释放，并影响不同过程，包括肿瘤发生，血管生成，耐药性和逃避免疫系统。这些功能归因于外来体的生物分子使其成为疾病早期诊断的有效标记物；此外，外来体已被应用于疫苗接种；外来体在对白血病细胞的免疫应答中的潜在作用使它们成为治疗白血病的有效免疫治疗剂；此外，外来体含量的变化也使它们有益这篇综述介绍了外泌体在血液系统恶性肿瘤发展中的作用，并评估了它们在这些恶性肿瘤治疗中的功能。