Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities,Advanced Science

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Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Advanced Science ( IF 14.3 ) Pub Date : 2020-10-19 , DOI: 10.1002/advs.202002611
Shuling Song _{1,

2} , Tamara Tchkonia ₃ , Jing Jiang ₄ , James L Kirkland ₃ , Yu Sun _{1,

4,

5}

Affiliation

Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age‐related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age‐related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age‐related disorders in the current era of precision medicine.

中文翻译：

针对衰老细胞实现更健康的衰老：挑战和机遇

衰老是结构稳态和功能完整性的生理下降，逐渐影响机体健康。衰老的一个主要标志是衰老细胞的积累，这些细胞在经历固有或环境压力后进入了不可逆的细胞周期停滞状态。尽管细胞衰老在多种生理事件中至关重要，但它在大量与年龄相关的病理中发挥着有害作用。最近在专门针对衰老细胞以改善健康衰老，或者推迟自然衰老和年龄相关疾病（一种称为衰老疗法的策略）方面取得的生物医学进展，引起了科学界和医学界的极大兴趣。强调了衰老研究面临的挑战，以及在当前精准医学时代可用于控制衰老和年龄相关疾病的治疗干预的潜在途径。

更新日期：2020-12-03

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