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A 3D‐Printed Self‐Adhesive Bandage with Drug Release for Peripheral Nerve Repair
Advanced Science ( IF 14.3 ) Pub Date : 2020-10-19 , DOI: 10.1002/advs.202002601 Jiumeng Zhang 1 , Yuwen Chen 1 , Yulan Huang 1 , Wenbi Wu 1 , Xianming Deng 2 , Haofan Liu 1 , Rong Li 1 , Jie Tao 1 , Xiang Li 3 , Xuesong Liu 4 , Maling Gou 1
Advanced Science ( IF 14.3 ) Pub Date : 2020-10-19 , DOI: 10.1002/advs.202002601 Jiumeng Zhang 1 , Yuwen Chen 1 , Yulan Huang 1 , Wenbi Wu 1 , Xianming Deng 2 , Haofan Liu 1 , Rong Li 1 , Jie Tao 1 , Xiang Li 3 , Xuesong Liu 4 , Maling Gou 1
Affiliation
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Peripheral nerve injury is a common disease that often causes disability and challenges surgeons. Drug‐releasable biomaterials provide a reliable tool to regulate the nerve healing‐associated microenvironment for nerve repair. Here, a self‐adhesive bandage is designed that can form a wrap surrounding the injured nerve to promote nerve regeneration and recovery. Via a 3D printing technique, the bandage is prepared with a special structure and made up of two different hydrogel layers that can adhere to each other by a click reaction. The nanodrug is encapsulated in one layer with a grating structure. Wrapping the injured nerve, the grating layer of the bandage is closed to the injured site. The drug can be mainly released to the inner area of the wrap to promote the nerve repair by improving the proliferation and migration of Schwann cells. In this study, the bandage is used to assist the neurorrhaphy for the treatment of complete sciatic nerve transection without obvious defect in rats. Results indicate that the self‐adhesive capacity can simplify the installation process and the drug‐loaded bandage can promote the repairing of injured nerves. The demonstrated 3D‐printed self‐adhesive bandage has potential application in assisting the neurorrhaphy for nerve repair.
中文翻译：
具有药物释放功能的 3D 打印自粘绷带用于周围神经修复
周围神经损伤是一种常见疾病，经常导致残疾并给外科医生带来挑战。可释放药物的生物材料为调节神经修复相关的微环境提供了可靠的工具。在这里，设计了一种自粘绷带，可以在受伤的神经周围形成包裹，以促进神经再生和恢复。通过3D打印技术，绷带具有特殊的结构，由两个不同的水凝胶层组成，可以通过点击反应相互粘附。纳米药物被封装在具有光栅结构的一层中。包裹受伤的神经，绷带的光栅层紧贴受伤部位。药物主要释放到包裹物的内部区域，通过改善雪旺细胞的增殖和迁移来促进神经修复。本研究采用该绷带辅助神经缝合术治疗大鼠坐骨神经完全横断且无明显缺损的情况。结果表明，自粘能力可以简化安装过程，载药绷带可以促进受伤神经的修复。经证实的 3D 打印自粘绷带在辅助神经缝合术修复神经方面具有潜在应用。
更新日期：2020-12-03
中文翻译：
具有药物释放功能的 3D 打印自粘绷带用于周围神经修复
周围神经损伤是一种常见疾病，经常导致残疾并给外科医生带来挑战。可释放药物的生物材料为调节神经修复相关的微环境提供了可靠的工具。在这里，设计了一种自粘绷带，可以在受伤的神经周围形成包裹，以促进神经再生和恢复。通过3D打印技术，绷带具有特殊的结构，由两个不同的水凝胶层组成，可以通过点击反应相互粘附。纳米药物被封装在具有光栅结构的一层中。包裹受伤的神经，绷带的光栅层紧贴受伤部位。药物主要释放到包裹物的内部区域，通过改善雪旺细胞的增殖和迁移来促进神经修复。本研究采用该绷带辅助神经缝合术治疗大鼠坐骨神经完全横断且无明显缺损的情况。结果表明，自粘能力可以简化安装过程，载药绷带可以促进受伤神经的修复。经证实的 3D 打印自粘绷带在辅助神经缝合术修复神经方面具有潜在应用。
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