Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis,Advanced Materials

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Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis
Advanced Materials ( IF 27.4 ) Pub Date : 2020-10-19 , DOI: 10.1002/adma.202003294
Nancy Soliman _{1,

2} , Gilles Gasser ₂ , Christophe M Thomas ₁

Affiliation

Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy due to their unique photophysical, photochemical, and biological properties. For effective treatment, they must be able to penetrate tumor cells effectively and selectively. The development of nanoscale carriers capable of delivering Ru(II) polypyridyl complexes has the potential to passively or selectively enhance their cellular uptake in tumor cells. Many different strategies have been explored to incorporate Ru(II) polypyridyl complexes into a variety of nanosized constructs, ranging from organic to inorganic materials. Herein, recent developments in nanomaterials loaded with Ru(II) polypyridyl complexes are highlighted. Their rational design, preparation, and physicochemical properties are described, and their potential applications in cancer therapy are eventually discussed.

中文翻译：

将 Ru(II) 多吡啶配合物掺入纳米材料用于癌症治疗和诊断

由于其独特的光物理、光化学和生物学特性，Ru(II) 多吡啶配合物是癌症治疗中非常受关注的化合物。为了有效治疗，它们必须能够有效和选择性地穿透肿瘤细胞。能够递送 Ru(II) 多吡啶基复合物的纳米级载体的开发有可能被动或选择性地增强它们在肿瘤细胞中的细胞摄取。已经探索了许多不同的策略来将 Ru(II) 多吡啶配合物结合到各种纳米结构中，从有机材料到无机材料。在此，重点介绍了载有 Ru(II) 多吡啶配合物的纳米材料的最新进展。描述了它们的合理设计、制备和理化性质，

更新日期：2020-11-25

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