In the European Union (EU), regulation of sterol demethylation inhibiting (DMI) fungicides is tightened due to their suspected endocrine disrupting properties. However, the new DMI fungicide mefentrifluconazole was reported to have high fungicidal activity with minimal adverse side effects. In addition, some evidence suggests inconsistent cross resistance between mefentrifluconazole and other azoles. In this study, mefentrifluconazole and other triazoles were examined for activity to select pathogens sensitive or resistant to DMIs using mycelial growth tests on fungicide-treated culture medium or spray trials using cucumber plants. Cross-resistance was confirmed for all of the fungal species tested but activity levels varied. The sensitivity of Monilinia fructicola from peach to mefentrifluconazole was higher compared to other DMIs. In contrast, the inhibitory activity of mefentrifluconazole was equal or slightly inferior compared to difenoconazole, tebuconazole, propiconazole in Colletotrichum spp., Alternaria alternaria sp. complex and Cercospora beticola isolated from peach and sugar beet, respectively. Similar tendencies (i.e. equal or slightly inferior activity and cross-resistance) were observed for cucumber powdery mildew (Podosphaera xanthii) resistant to triflumizole, myclobutanil, and difenoconazole. Despite cross-resistance to other DMIs, mefentrifluconazole is a promising fungicide for fungal disease control on peach and other crops, with a reportedly more favorable toxicity profile.

中文翻译：

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DMI抗性真菌病原体对新型杀菌剂甲芬氟康唑的交叉耐药性

在欧盟 (EU)，甾醇去甲基化抑制 (DMI) 杀菌剂因其可疑的内分泌干扰特性而加强了监管。然而，据报道，新的 DMI 杀菌剂甲芬三氟康唑具有高杀菌活性，且副作用极小。此外，一些证据表明甲芬三氟康唑和其他唑类药物之间存在不一致的交叉耐药性。在这项研究中，使用杀菌剂处理的培养基上的菌丝体生长测试或使用黄瓜植物的喷雾试验，检查了甲芬三氟康唑和其他三唑类药物在选择对 DMI 敏感或抗性的病原体方面的活性。对所有测试的真菌物种都确认了交叉抗性，但活性水平各不相同。与其他 DMI 相比，桃中的果核念珠菌对甲芬三氟康唑的敏感性更高。相比之下，与苯醚甲环唑、戊唑醇、丙环唑相比，甲芬三氟康唑对炭疽菌属、链格孢属的抑制活性相等或略差。分别从桃和甜菜中分离出的复合物和尾孢菌。黄瓜白粉病 (Podosphaera xanthii) 对三氟咪唑、丁苯菌胺和苯醚甲环唑的抗性也观察到了类似的趋势（即活性和交叉抗性相等或稍差）。尽管与其他 DMI 存在交叉抗性，但甲芬氟康唑是一种很有前途的杀菌剂，可用于防治桃和其他作物的真菌病害，据报道具有更有利的毒性特征。分别从桃和甜菜中分离出的复合物和尾孢菌。黄瓜白粉病 (Podosphaera xanthii) 对三氟咪唑、丁苯菌胺和苯醚甲环唑的抗性也观察到了类似的趋势（即活性和交叉抗性相等或稍差）。尽管与其他 DMI 存在交叉抗性，但甲芬氟康唑是一种很有前途的杀菌剂，可用于防治桃和其他作物的真菌病害，据报道具有更有利的毒性特征。分别从桃和甜菜中分离出的复合物和尾孢菌。黄瓜白粉病 (Podosphaera xanthii) 对三氟咪唑、丁苯菌胺和苯醚甲环唑的抗性也观察到了类似的趋势（即活性和交叉抗性相等或稍差）。尽管与其他 DMI 存在交叉抗性，但甲芬氟康唑是一种很有前途的杀菌剂，可用于防治桃和其他作物的真菌病害，据报道具有更有利的毒性特征。