A face-centered Central Composite Design (CCD) was used for nopol synthesis from turpentine oil over Sn/MCM-41 catalyst synthesized with sodium silicate as silicon source and incorporating Sn by wetness impregnation using SnCl₂.2H₂O as metal source. The catalyst was characterized by XRD, NH₃-TPD and UV–vis-DRS. The catalyst was used four times without an apparent loss of catalytic activity and with no leaching of Sn. The CCD was constructed from 2⁴ factorial points, eight axial points and seven central points, with time, paraformaldehyde to β-pinene molar ratio, catalyst concentration and solvent to β-pinene ratio as factors. Three response variables were selected (β-pinene conversion, nopol selectivity and nopol yield), and second order models were obtained taking into account all possible effects and identifying the non statistically significant effects. The optimal values found by response surface methodology were 71 %, 99 % and 61 % for conversion, selectivity and yield, respectively. The reactions were carried out under the established optimal conditions and the error varied between 2.14 and 2.63 %. Finally, the assumptions of independence, normality and homoscedasticity for each of the models were satisfactorily validated.

以面心为中心的中央复合设计（CCD）用于由松节油在以硅酸钠为硅源合成并通过湿法浸渍以SnCl ₂ .2H ₂ O为金属源的Sn / MCM-41催化剂上合成Nopol 。该催化剂的特征在于XRD，NH ₃ -TPD和UV-vis-DRS。催化剂使用了四次而没有明显的催化活性损失并且没有锡的浸出。CCD是从2 ⁴阶乘点，八个轴点和七个中心点，以时间，多聚甲醛与β-pine烯的摩尔比，催化剂浓度和溶剂与β-pine烯的比为因素。选择了三个响应变量（β-pine烯转化率，nopol选择性和nopol产量），并考虑了所有可能的影响并确定了非统计学显着影响，从而获得了二阶模型。通过响应面法得出的最佳转化率，选择性和产率分别为71％，99％和61％。在确定的最佳条件下进行反应，误差在2.14和2.63％之间变化。最后，令人满意地验证了每个模型的独立性，正态性和均方差性假设。