Leptospirosis is a global disease that affects humans and animals, impacting public health and the economy. The symptoms caused by Leptospira infection can vary from mild to severe, affecting liver, lungs, and kidneys. The host-pathogen interaction in leptospirosis is still poorly understood, but there is evidence for the role of the host immune response in the pathogenesis. Chemokines are a family of structurally-related low-molecular-mass proteins (8–14 kDa) that signal the recruitment of leukocytes. In this study the profile of 22 chemokines were evaluated in liver and kidney of three mice strains with different phenotypes of susceptibility to leptospirosis. We extended our previously reported observations showing that expression of chemokines with homeostatic function, activation and chemotaxis of leukocytes are essential to modulate and to induce resistance to leptospirosis. Our findings support that an early induction of CXC chemokines in resistant BALB/c mice can be associated with the control of the infection. The correlation of chemokine expression between liver and kidney observed in BALB/c suggests that a balance of chemokine induction in the organs may contribute to resistance to leptospirosis.

钩端螺旋体病是一种全球性疾病，影响人类和动物，影响公共卫生和经济。钩端螺旋体引起的症状感染程度从轻到重不等，会影响肝，肺和肾脏。钩端螺旋体病中的宿主-病原体相互作用仍然知之甚少，但是有证据表明宿主免疫应答在发病机理中的作用。趋化因子是结构相关的低分子质量蛋白（8–14 kDa）的家族，可发出白细胞募集的信号。在这项研究中，评估了三种对钩端螺旋体病具有不同表型的小鼠品系在肝脏和肾脏中22种趋化因子的分布。我们扩展了我们先前报道的观察结果，这些观察结果表明趋化因子具有稳态功能，白细胞活化和趋化性的表达对于调节和诱导对钩端螺旋体病的抵抗至关重要。我们的发现支持在抗性BALB / c小鼠中早期诱导CXC趋化因子可与感染控制相关。在BALB / c中观察到的肝肾之间趋化因子表达的相关性表明，器官中趋化因子诱导的平衡可能有助于抵抗钩端螺旋体病。