We developed a prototype genomic archiving and communications system to securely store genome data and provide clinical decision support (CDS). This system operates on a client-server model. The client encrypts the data, and the server stores data and performs the computations necessary for CDS. Computations are directly performed on encrypted data, and the client decrypts results. The server cannot decrypt inputs or outputs, which provides strong guarantees of security. We have validated our system with three genomics-based CDS applications. The results demonstrate that it is possible to resolve a long-standing dilemma in genomic data privacy and accessibility, by using a principled cryptographical framework and a mathematical representation of genome data and CDS questions.

我们开发了原型基因组存档和通信系统，以安全地存储基因组数据并提供临床决策支持 (CDS)。该系统在客户端-服务器模型上运行。客户端加密数据，服务器存储数据并执行 CDS 所需的计算。直接对加密数据进行计算，客户端解密结果。服务器无法解密输入或输出，这提供了强有力的安全保证。我们已经使用三个基于基因组学的 CDS 应用程序验证了我们的系统。结果表明，通过使用原则性的加密框架以及基因组数据和 CDS 问题的数学表示，可以解决基因组数据隐私和可访问性方面长期存在的困境。