Continuing decline in the prevalence of cerebral palsy in Denmark for birth years 2008–2013,European Journal of Paediatric Neurology

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Continuing decline in the prevalence of cerebral palsy in Denmark for birth years 2008–2013
European Journal of Paediatric Neurology ( IF 2.3 ) Pub Date : 2020-10-17 , DOI: 10.1016/j.ejpn.2020.10.003
Mads Langager Larsen ₁ , Gija Rackauskaite ₂ , Gorm Greisen ₃ , Bjarne Laursen ₄ , Peter Uldall ₁ , Lone Krebs ₅ , Christina Engel Hoei-Hansen ₁

Affiliation

Aim

To quantify and analyse the prevalence and clinical features of cerebral palsy (CP) in Denmark for birth years 2008–2013 and compare results with previous periods.

Method

A nationwide register-based study covering all children with a confirmed diagnosis of CP born in Denmark. Information about CP subtype, aetiology and severity was collected from the Cerebral Palsy Follow-up Program and supplemented from medical files. Data from the Danish Medical Birth Register was included, and the results were compared to previous data from the Danish National Cerebral Palsy Register. Prevalence per 1000 live births and proportions were analysed using the Cochran-Armitage test for trend.

Results

The period covered 368,618 live births and 636 children with CP, making the overall prevalence for the period 1.73 per 1000 live births. This was significantly lower than the prevalence of 1.99 for the previous period 1999–2007 (p = 0.004). The decline in prevalence between the two periods was mainly due to a decrease in children with bilateral spastic and dyskinetic CP born after 37 gestational weeks. The decline in prevalence was accompanied by a smaller proportion of children with associated impairment.

Conclusion

We found a decrease in prevalence and severity in CP among Danish children. The decline was most pronounced in children born after 37 gestational weeks with severe subtypes of CP. National guidelines that recommend induction of labour before the completion of week 42 and therapeutic hypothermia for term neonates with hypoxic-ischaemic encephalopathy, may have contributed to the decline.

中文翻译：

2008-2013 年出生年份丹麦脑瘫患病率持续下降

目的

量化和分析 2008-2013 年出生年份丹麦脑瘫 (CP) 的患病率和临床特征，并将结果与之前时期进行比较。

方法

一项全国范围的登记研究，涵盖所有在丹麦出生的确诊患有脑瘫的儿童。有关 CP 亚型、病因和严重程度的信息是从脑瘫随访计划中收集的，并从医疗档案中进行补充。其中包括丹麦医学出生登记处的数据，并将结果与丹麦国家脑瘫登记处之前的数据进行比较。使用 Cochran-Armitage 趋势检验分析每 1000 名活产婴儿的患病率和比例。

结果

该时期涵盖了 368,618 名活产儿和 636 名脑瘫儿童，使得该时期的总患病率为每 1000 名活产儿 1.73 人。这明显低于 1999-2007 年前期的患病率 1.99 (p = 0.004)。两个时期之间患病率的下降主要是由于孕37周后出生的双侧痉挛性和运动障碍性CP患儿的减少。患病率下降的同时，患有相关障碍的儿童比例也有所下降。