BACKGROUND Aspirin has been associated with a decreasing risk of subarachnoid hemorrhage due to its anti-inflammatory mechanism of action and potential protective properties against aneurysm growth. OBJECTIVE To determine the association between aneurysmal subarachnoid hemorrhage and aspirin use. METHODS A systematic review of the literature and a meta-analysis were performed across the PubMed database. The following keywords were used: "aspirin, acetylsalicylic acid, 2-acetyloxy-benzoic acid, ruptured intracranial aneurysm, aneurysmal subarachnoid hemorrhage, spontaneous subarachnoid hemorrhage, intracerebral hemorrhage, spontaneous aneurysmal hemorrhage, spontaneous intracerebral bleeding". Studies that were performed with animals or analyzed patients with traumatic brain injury were excluded. A total of five studies were included in our meta-analysis, with a total of 19,222 patients evaluated. Statistical analysis was performed to determine the association between the use of aspirin and the risk of subarachnoid hemorrhage. RESULTS Aspirin use reduce the risk of subarachnoid hemorrhage (odds ratio [OR] 0.51, 95 % confidence interval [CI] 0.34-0.76). CONCLUSION Although some previous studies suggested that aspirin may potentially reduce the risk of subarachnoid hemorrhage, our meta-analysis found an association between the reduction of risk of aneurysmal subarachnoid hemorrhage.

中文翻译：

---

阿司匹林使用与蛛网膜下腔出血的关系：系统评价和荟萃分析

背景 由于阿司匹林的抗炎作用机制和对动脉瘤生长的潜在保护特性，阿司匹林与降低蛛网膜下腔出血的风险有关。目的 确定动脉瘤性蛛网膜下腔出血与阿司匹林使用之间的关联。方法 对 PubMed 数据库进行系统性文献回顾和荟萃分析。使用了以下关键词：“阿司匹林、乙酰水杨酸、2-乙酰氧基-苯甲酸、颅内动脉瘤破裂、动脉瘤性蛛网膜下腔出血、自发性蛛网膜下腔出血、脑内出血、自发性动脉瘤出血、自发性脑内出血”。对动物进行的研究或对脑外伤患者进行分析的研究被排除在外。我们的荟萃分析共纳入了五项研究，共评估了 19,222 名患者。进行统计分析以确定阿司匹林的使用与蛛网膜下腔出血风险之间的关联。结果 使用阿司匹林可降低蛛网膜下腔出血的风险（优势比 [OR] 0.51，95% 置信区间 [CI] 0.34-0.76）。结论 尽管之前的一些研究表明阿司匹林可能会降低蛛网膜下腔出血的风险，但我们的荟萃分析发现动脉瘤性蛛网膜下腔出血的风险降低之间存在关联。结果 使用阿司匹林可降低蛛网膜下腔出血的风险（优势比 [OR] 0.51，95% 置信区间 [CI] 0.34-0.76）。结论 尽管之前的一些研究表明阿司匹林可能会降低蛛网膜下腔出血的风险，但我们的荟萃分析发现动脉瘤性蛛网膜下腔出血的风险降低之间存在关联。结果 使用阿司匹林可降低蛛网膜下腔出血的风险（优势比 [OR] 0.51，95% 置信区间 [CI] 0.34-0.76）。结论 尽管之前的一些研究表明阿司匹林可能会降低蛛网膜下腔出血的风险，但我们的荟萃分析发现动脉瘤性蛛网膜下腔出血的风险降低之间存在关联。