Studies in recent years have significantly expanded, refined, and redefined the repertoire of transporters and other proteins involved in iron and manganese (Mn) transport and homeostasis. In this review, we discuss highlights of the recent literature on iron and Mn transport, focusing on the roles of membrane transporters and related proteins. Studies are considered from the vantage point of main organs, tissues, and cell types that actively control whole-body iron or Mn homeostasis, with emphasis on studies in which in vivo metal transport was measured directly or implicated by using knockout mouse models. Overviews of whole-body and cellular iron and Mn homeostasis are also provided to give physiological context for key transporters and to highlight how they participate in the uptake, intracellular trafficking, and efflux of each metal. Important similarities and differences in iron and Mn transport are noted, and future research opportunities and challenges are identified.

近年来的研究已显着扩展、完善和重新定义了转运蛋白和其他参与铁和锰 (Mn) 转运和体内平衡的蛋白质。在这篇综述中，我们讨论了最近关于铁和锰转运的文献的亮点，重点是膜转运蛋白和相关蛋白质的作用。从积极控制全身铁或锰稳态的主要器官、组织和细胞类型的有利位置考虑研究，重点是通过使用敲除小鼠模型直接测量或涉及体内金属转运的研究。还提供了全身和细胞铁和锰稳态的概述，以提供关键转运蛋白的生理背景，并强调它们如何参与每种金属的摄取、细胞内运输和流出。