The mitochondrial permeability transition pore (mPTP) opening is involved in the pathophysiology of multiple cardiac diseases, such as ischemia/reperfusion injury and heart failure. A growing number of evidence provided by proteomic screening techniques has demonstrated the role of post-translational modifications (PTMs) in several key components of the pore in response to changes in the extra/intracellular environment and bioenergetic demand. This could lead to a fine, complex regulatory mechanism that, under pathological conditions, can shift the state of mitochondrial functions and, thus, the cell's fate. Understanding the complex relationship between these PTMs is still under investigation and can provide new, promising therapeutic targets and treatment approaches. This review, using a systematic review of the literature, presents the current knowledge on PTMs of the mPTP and their role in health and cardiac disease.

线粒体通透性过渡孔（mPTP）的开放涉及多种心脏疾病的病理生理，例如缺血/再灌注损伤和心力衰竭。蛋白质组学筛选技术提供的越来越多的证据表明，翻译后修饰（PTM）在孔的几个关键成分中的作用是响应细胞外/细胞内环境和生物能需求的变化。这可能导致一种精细的复杂调节机制，在病理情况下，它可以改变线粒体功能状态，进而改变细胞命运。仍在研究这些PTM之间的复杂关系，并且可以提供新的，有希望的治疗靶标和治疗方法。通过系统地回顾文献，